Characteristics of human neural stem cells In Vitro and after transplantation into rat brain |
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| Authors: | M A Aleksandrova O V Podgornyi M V Marei R A Poltavtseva E B Tsitrin D V Gulyaev L V Cherkasova A V Revishchin L I Korochkin N G Khrushchov G N Sukhikh |
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| Affiliation: | (1) Center of Obstetrics, Gynecology, and Perinatology, Russian Academy of Medical Sciences, Russia;(2) Institute of Ecological and Evolutional Problems, Russian Academy of Sciences, Russia;(3) Institute of Gene Biology, Russian Academy of Sciences, Moscow;(4) Institute of Developmental Biology, Russian Academy of Sciences, Russia |
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| Abstract: | We studied the effect of culturing conditions on the fate of human neural stem cells after transplantation into rat brain. Human neural stem cells cultured in the presence of mitogens without LIF migrated along the ependyma and cerebral vessels of recipients, but to a great extent degenerated by the 20th day after transplantation. Neural stem cells cultured with LIF migrated, apart from the above mentioned pathways, in the cortex and hippocampus, well survived; proliferating cells were retained 30 days after transplantation.__________This revised version was published online in July 2005 with the addition of the issue title and article categoryTranslated from Kletochnye Tekhnologii v Biologii i Meditsine, Vol. 1, No. 1, pp. 13–19, January, 2005 |
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| Keywords: | human neural stem cells tissue culture xenotransplantation immunohistochemistry |
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