Comparative analysis of differentiation and behavior of human neural and mesenchymal stem cells In Vitro and In Vivo |
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| Authors: | M A Aleksandrova G T Sukhikh R K Chailakhyan O V Podgornyi M V Marei R A Poltavtseva Yu V Gerasimov |
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| Affiliation: | (1) Institute of Developmental Biology, Russian Academy of Sciences, Russia;(2) Center of Obstetrics, Gynecology, and Perinatology, Russian Academy of Medical Sciences, Russia;(3) N. F. Gamaleya Institute of Epidemiology and Microbiology, Moscow |
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| Abstract: | Comparative analysis of differentiation of human neural and mesenchymal stem cells in tissue culture and after transplantation
into the brain was carried out using the same antibody set. Neural stem cells differentiated into all types of neural cells,
are retained after transplantation, migrate, and form reciprocal relationships with the recipient brain. Mesenchymal stem
cells were incapable of neural development under conditions of common culturing or after transplantation and retained the
fibroblast-like status. Recipient filaments grew into mesenchymal stem cell transplants containing no neural cells due to
local changes in the extracellular matrix at the site of transplantation.
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Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 1, pp. 44–52, January, 2006 |
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| Keywords: | neural stem cells mesenchymal stem cells differentiation filament growth immunohistochemistry |
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