沙培林腔内注射对乳腺癌改良根治术后皮下积液的疗效

目的:观察沙培林腔内注射治疗乳腺癌改良根治术后皮下积液的疗效及安全性。方法:选择行乳腺癌改良根治术后发生皮下积液患者60例,随机分为观察组和对照组,每组30例。观察组行抽净积液后腔内注射沙培林混合液,3h后抽净药液,再用绷带加压包扎积液创面;对照组仅以50%葡萄糖腔内注射,其余步骤相同。观察两组皮下积液改善的效果以及发热和局部皮肤坏死等不良反应。结果:治疗前两组积液量差异无统计学意义(164.45±36.22ml vs 172.41±45.37ml,P0.05);第一次治疗后和第二次治疗后,观察组积液量均少于对照组(55.43±36.29ml vs 132.31±41.65ml,18.39±15.47ml vs 69.42±38.75ml;P0.05),积液完全消失时间(3.22±0.64天vs11.84±1.83天)明显短于对照组(P0.05)。两组发热率均为3.33%(1/30),差异无统计学意义(P0.05),均未发生皮肤坏死事件。结论:局部腔内注射沙培林可很快减少乳腺癌改良根治术后皮下积液,且使用方便、安全。

Clinical Observation of Sapylin Local Injection in the Treatment of Postoperative Seroma after Breast Cancer Modified Radical Mastectomy

Objective：To evaluate safety and clinical efficacy of Sapylin in the treatment of postoperative seroma after breast cancer modified radical mastectomy.Method：60 patients with postoperative seroma after breast cancer modi-fied radical mastectomy were included.These patients were randomly divided into observation group and control group,30 cases in each group.In control group,while additional articular injection Sapylin treatment in observation group;they underwent conventional fluid drainage ＋ bandaged.Seroma improvement after breast cancer modified radical mastectomy,fever,local skin necrosis and so on adverse reactions were compared between two groups.Re-sults：The two groups showed no significant difference in the incidence of postoperative fever （3.33% vs 3.33%,P〉0.05）,skin necrosis did not occur （0% vs 0%,P〉0.05）.Effusion differences between the two groups before treatment was not statistically significant（164.45±36.22ml vs 172.41±45.37ml,P〉0.05）;After the first and second treatment,effusion in the observation group was significantly less than the control group （55.43±36.29ml vs 132.31±41.65ml,18.39±15.47ml vs 69.42±38.75ml,P〈0.05）Conclusion：Articular injection Sapylin can significantly shorten the duration of treatment of postoperative seroma after breast cancer modified radical mastecto-my.It is easy to use and it is safe.