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Ectopic lymphoid tissues support local immunoglobulin production in patients with chronic rhinosinusitis with nasal polyps |
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| Authors: | Jia Song Hai Wang Ya-Na Zhang Ping-Ping Cao Bo Liao Zhe-Zheng Wang Li-Li Shi Yin Yao Guan-Ting Zhai Zhi-Chao Wang Li-Meng Liu Ming Zeng Xiang Lu Heng Wang Xiang-Ping Yang Di Yu Claus Bachert Zheng Liu |
| Affiliation: | 1. Department of Otolaryngology–Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;4. Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;2. Department of Otolaryngology-Head and Neck Surgery, Guangzhou Women and Children''s Medical Center, Guangzhou, China;3. No.1 Middle School affiliated to Central China Normal University, Wuhan, China;5. Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australia;6. Upper Airways Research Laboratory, Ghent University, Ghent, Belgium |
| Abstract: | |
| Keywords: | Ectopic lymphoid tissue immunoglobulin lymphoid aggregate lymphorganogenesis AID Activation-induced cytidine deaminase BAFF B cell–activating factor of the TNF family Bcl B-cell lymphoma CD21L CD21 ligand CRSsNP Chronic rhinosinusitis without nasal polyps CRSwNP Chronic rhinosinusitis with nasal polyps DC Dendritic cell eLT Ectopic lymphoid tissue FDC Follicular dendritic cell GC Germinal center HEV High endothelial venule ICAM-1 Intercellular adhesion molecule 1 ICOS Inducible costimulator LT Lymphotoxin LTβR Lymphotoxin β receptor NP Nasal polyp sIgE Specific IgE Follicular helper T VCAM-1 Vascular cell adhesion molecule 1 |
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