| miRNA对T细胞分化与功能的调节作用 |
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| 引用本文： | 余婷,肖斌.miRNA对T细胞分化与功能的调节作用[J].生命的化学,2014(5):701-707. |
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| 作者姓名： | 余婷 肖斌 |
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| 作者单位： | 第三军医大学药学系微生物与生化药学教研室暨国家免疫生物制品工程技术研究中心,重庆400038 |
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| 基金项目： | 国家自然科学基金项目（81202310） |
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| 摘 要： | miRNA是一类长度为19~24 nt的内源性非编码小分子RNA,主要通过抑制mRNA的翻译或使其降解对靶基因实现转录后水平的调控。miRNA与T细胞的分化及功能密切相关,参与自身免疫性疾病、感染性疾病、肿瘤等多种病理过程的免疫调控。本文综述了近年来发现的miRNA在T细胞分化与功能调节中的作用,特别是其在抗感染与抗肿瘤免疫中的作用。
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| 关 键 词： | 微RNA T细胞 抗感染免疫 抗肿瘤免疫 |
Research progress of miRNA-mediated regulation for T cell differentiation and function |
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| YU Ting,XIAO Bin.Research progress of miRNA-mediated regulation for T cell differentiation and function[J].Chemistry of Life,2014(5):701-707. |
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| Authors: | YU Ting XIAO Bin |
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| Affiliation: | (National Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing 400038, China) |
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| Abstract: | microRNAs （miRNAs） are a class of endogenously expressed small non-coding RNAs with about 19-24 nucleotides in length, which carry out the post-transtcriptional regulation of the target genes through inhibiting the translation or degradation of mRNAs. MiRNAs are closely related with the differentiation and functions of T cells and participate in the immunoregulation of autoimmune diseases, infectious diseases and tumor. The miRNA-mediated regulation of T cell differentiation and function, especially the role of miRNA in anti-infection immunity and anti-tumor immunity has been reviewed in this paper. |
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| Keywords: | microRNA T cell anti-infection immunity anti-tumor immunity |
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