| Nrf2基因敲除小鼠的繁育及生长发育的生物学特性 |
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| 引用本文： | 田小芸,恽时锋,郭联庆,董敏,许龙祥,赵志刚.Nrf2基因敲除小鼠的繁育及生长发育的生物学特性[J].中国实验动物学杂志,2009(2):50-52. |
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| 作者姓名： | 田小芸 恽时锋 郭联庆 董敏 许龙祥 赵志刚 |
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| 作者单位： | 南京军区南京总医院比较医学科,全军实验动物科普与伦理教育基地,南京210002 |
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| 摘 要： | 目的了解ICR-Nrf2小鼠的生物学特性。方法用原种繁殖扩群,观察繁殖性能及仔鼠的生长发育。结果ICR-Nrf2--/-与ICR-Nrf2-＋/＋比,总的产仔数与离乳数减少（P〈0.01或P〈0.05）;体重在出生后第3周时差异有显著性（P〈0.01）,第5周至第25周时同性别间差异非常显著（P〈0.01）。结论Nrf2基因缺失小鼠的产仔数、离乳数均少于野生型小鼠,仔鼠的生长速度也较野生型小鼠慢。
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| 关 键 词： | ICR-Nrf2小鼠 基因敲除 生物学特性 |
Reproductive and Developmental Features of Nrf2-knockout ICR Mice |
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| TIAN Xiao-yun,YUN Shi-feng,GUO Lian-qing,Dong Min,XU Long-xiang,ZHAO Zhi-gang.Reproductive and Developmental Features of Nrf2-knockout ICR Mice[J].Chinese Journal of Laboratory Animal Science,2009(2):50-52. |
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| Authors: | TIAN Xiao-yun YUN Shi-feng GUO Lian-qing Dong Min XU Long-xiang ZHAO Zhi-gang |
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| Affiliation: | (Department of Comparative Medicine, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China) |
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| Abstract: | Objective To study the reproductive and developmental features of Nrf2-knockout ICR mice. Methods Comparing with the wild type mice, the reproduction indexes of 12 pairs of Nrf2-knockout ICR mice, such as birth duration, birth and weaned numbers, were recorded. Their body weight at different weeks of age were also examined. Results In comparison with Nrf2- ＋ / ＋ mice, the decreases of total birth and weaned number in Nrf2- - / - mice were statistically significant （ P 〈 0.01 or P 〈 0.05） ; their average weights of 5 - 25 week-old mice were also decreased significantly （ P 〈 0.01 ）. Conclusion The Nrf2- - / - mice show a weaker ability of reproduction and growth than Nrf2- ＋ / ＋ mice. |
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| Keywords: | Mice gene knockout Reproductive features Developmental features |
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