葡激酶突变体对高脂喂养大鼠血液常规指标的影响

目的研究葡激酶突变体（SakM）对高脂喂养大鼠血液常规的影响。方法选取60只Wistar大鼠，随机分为高脂药物组、高脂生理盐水组、正常药物对照组、正常生理盐水对照组，静脉注射SakM到大鼠体内，剂量按照0．5mg／kg体重，2d注射一次，连续15次，观察SakM对血液常规的影响。结果SakM对正常动物血液常规指标没有影响，但是能够改善高脂喂养动物的血液常规指标结论SakM长期使用不会影响正常动物血液常规指标，具有使用安全性，同时还能用来调节高脂喂养动物的血液常规指标。

Influence of Stapylokinase Mutant on the Hematological Parameter of the High Fat Diet Rat

Objective To investigate the effect of staphylokinase mutant （SakM） on the rats fed on high fat diet. Methods 60 Wistar rats were randomly divided into 4 groups ： high fat diet plus SakM, high fat diet plus normal saline, routine diet plus SakM, and routine diet plus normal saline. The former two groups received SakM（0.5 mg/kg, once per two days for 15 times）, and the latter two groups received normal saline in the same way. The routine blood indexes were observed. Results The SakM can not influence the blood indexes of the rats fed on normal diet, however, the SakM can improve the routine blood indexes of the rats fed on high fat diet. Conclusions The long-term injection of SakM did nothing with the routing blood indexes of the rats fed on normal diet, and the SakM is sate for long-term use, which can be used to regulate the blood indexes of the rats fed on high fat diet.