| 锌转运体ZNT7在Alzheimer病动物模型APP/PS1转基因鼠脑内的表达 |
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| 引用本文： | 王辛,荣明,张丽红,王思玲,王占友.锌转运体ZNT7在Alzheimer病动物模型APP/PS1转基因鼠脑内的表达[J].中国组织化学与细胞化学杂志,2008,17(3):256-259. |
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| 作者姓名： | 王辛 荣明 张丽红 王思玲 王占友 |
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| 作者单位： | 1. 中国医科大学基础医学院组织胚胎学教研室,沈阳,110001
2. 沈阳药科大学药剂系,沈阳,110016 |
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| 基金项目： | 教育部高等学校博士学科点专项科研基金
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国家自然科学基金 |
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| 摘 要： | 目的研究阿尔茨海默病（Alzheimer disease,AD）模型小鼠APP/PS1转基因小鼠脑内锌转运体ZNT7的分布和表达,探讨ZNT7参与Aβ老年斑形成的机理。方法应用免疫组织化学染色观察ZNT7在脑内分布情况,应用Western Blot方法分析ZNT7在APP/PS1转基因小鼠大脑内的表达。结果ZNT7免疫阳性反应产物主要分布在APP/PS1转基因小鼠大脑皮层、纹状体和海马的老年斑内,强阳性的ZNT7免疫产物定位于老年斑的核心。Western Blot分析结果表明ZNT7在APP/PS1转基因小鼠大脑内的表达明显高于野生型小鼠。结论ZNT7在APP/PS1转基因小鼠大脑内的高表达以及在Aβ老年斑的定位,提示ZNT7可能参与了锌离子在老年斑内的聚集,进而参与了APP/PS1转基因小鼠大脑内老年斑的形成。
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| 关 键 词： | 锌转运体 β-淀粉样蛋白 阿尔茨海默病 APP/PS1转基因鼠 |
EXPRESSION OF ZINC TRANSPORTER ZNT7 IN APP/PS1 TRANSGENIC MOUSE BRAIN |
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| Wang Xin,Rong Ming,Zhang Lihong,Wang Siling,Wang Zhanyou.EXPRESSION OF ZINC TRANSPORTER ZNT7 IN APP/PS1 TRANSGENIC MOUSE BRAIN[J].Chinese Journal of Histochemistry and Cytochemistry,2008,17(3):256-259. |
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| Authors: | Wang Xin Rong Ming Zhang Lihong Wang Siling Wang Zhanyou |
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| Affiliation: | Wang Xin1,Rong Ming1,Zhang Lihong1,Wang Siling2,Wang Zhanyou1(1 Department of Histology , Embryology,College of Basic Medical Sciences,China Medical University,Shengyang 110001,2 School of Pharmacy,Shenyang Pharmaceutical University,Shengyang 110016,China) |
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| Abstract: | Objective To investigate the expression of the zinc transporter ZNT7 and its possible role in senile plaque formation in the brain of an animal model of Alzheimer's disease,the APP/PS1 transgenic mouse.Methods Immunohistochemistry of ZNT7 was performed to observe the distribution of ZNT7 immunoreactivity,and Western blotting was used to analyze the expression of ZNT7 in the APP/PS1 transgenic mouse brain.Results ZNT7 immunoproducts were predominately distributed in the senile plaques in the neo-cortex,stria... |
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| Keywords: | Zinc transporter β-Amyloid protein Alzheimer disease APP/PS1 transgenic mouse |
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