Translocation of Bax in rat hepatocytes cultured with ferric nitrilotriacetate |
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Authors: | Yajun Zhou Hongshan Chen Baoxi Sha Dengbing Yao Jianhua Shi Xinshun Ge Li Yin Yi Cao |
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Affiliation: | Department of Biochemistry and Molecular Biology, Medical College, Nan Tong University 226001, Jiangsu Province, PR China. zhouyajun64@hotmail.com |
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Abstract: | Hepatic fibrosis occurs after many years of iron overload in liver. An effective iron deposition model induced by ferric nitrilotriacetate (FeNTA) in cultured rat hepatocytes was assumed. It has been shown that treatment of rat hepatocytes with FeNTA lead to oxidative stress and hepatocyte apoptosis. Hepatocyte apoptosis can promote liver fibrosis. The mechanisms of hepatocyte apoptosis induced by FeNTA have not yet been fully elucidated. The present study demonstrated that FeNTA-induced hepatocyte apoptosis was related to Bax translocation, cytochrome c release, and caspase-3 activation. |
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