| 纳洛酮对发热大鼠下丘脑中cAMP和腹中膈区AVP含量的影响 |
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| 作者姓名： | Zhao HY Qin X Cao Y Yang Y Zhao SF |
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| 作者单位： | 中国医科大学基础医学院生理学教研室,辽宁沈阳110001 |
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| 基金项目： | 国家自然科学基金资助项目（30270198） |
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| 摘 要： | 目的：研究纳洛酮对白细胞介素-1β（IL-1β）致热大鼠发热反应的影响及机制。方法：经大鼠侧脑室微量注射IL-1β建立发热模型,观察纳洛酮对发热大鼠体温的影响,并测定下丘脑中环磷酸腺苷（cAMP）和腹中膈区精氨酸加压素（AVP）含量。结果：纳洛酮减弱了IL-1β致热效应,同时下丘脑中cAMP和腹中膈区AVP含量也相应减少（P〈0．01）。结论：纳洛酮能够抑制大鼠IL-1β性发热,其机制可能是抑制下丘脑中cAMP的合成,并且促进腹中膈区AVP的释放。
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| 关 键 词： | 发热 纳洛酮 白细胞介素-1β 环磷酸腺苷 精氨酸加压素 |
Effects of naloxone on the contents of camp in hypothalamus and AVP in ventral septal area in fever rats |
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| Zhao HY,Qin X,Cao Y,Yang Y,Zhao SF.Effects of naloxone on the contents of camp in hypothalamus and AVP in ventral septal area in fever rats[J].Chinese Journal of Applied Physiology,2009,25(3):408-410. |
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| Authors: | Zhao Hong-yan Qin Xin Cao Yu Yang Yu Zhao Shu-fen |
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| Affiliation: | Department of Physiology, China Medical University, Shenyang 110001, China. |
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| Abstract: | Aim： To study the effects and mechanism of naloxone on the febrile response in IL-1β-indueed fever rats. Methods： The fever model was established by intracerebroventricular injection of IL-1β in rats. The effect of naloxone on the body temperature of fever rats was observed. The contents of cAMP in hypothalamus and AVP in VSA were detected. Results： Naloxone alleviated IL-1β-induced fever and the contents of cAMP in hypothalamus and AVP in VSA were correspondingly decreased（ P 〈 0.01 ）. Conclusion： Naloxone could inhibit IL-1β-induced fever in rats, and the mechanism might be due to inhibiting synthesis of cAMP in hypothalamus and promoting release of AVP in VSA. |
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| Keywords: | fever naloxone IL-1β cAMP AVP |
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