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| 结直肠癌中DNA甲基化研究进展 | |
| 引用本文： | 张华,陈鸣,黄庆,府伟灵.结直肠癌中DNA甲基化研究进展[J].生物技术通讯,2009,20(1):118-122. |
| 作者姓名： | 张华 陈鸣 黄庆 府伟灵 |
| 作者单位： | 1. 贵州省人民医院,检验科,贵州,贵阳,550002 2. 第三军医大学,附属大坪医院检验科,重庆,400042 3. 第三军医大学,附属西南医院检验科,重庆,400038 |
| 基金项目： | 贵州省科技攻关项目，重庆市自然科学基金 |
| 摘 要： | CpG岛是人类基因组中富含CpG二核苷酸的DNA序列，主要位于基因启动子区，大小约为100-1000bp，与约60％编码基因相关。DNA中CpG岛甲基化可导致抑癌基因的表观遗传学转录失活，直接参与肿瘤的发生机制。近年来，甲基化已成为表观遗传学研究的焦点。我们简要综述了DNA甲基化在结直肠癌中的研究进展。 |
| 关 键 词： | DNA甲基化 CpG岛 结直肠癌 |
DNA Methylation in Colorectal Carcinoma |
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| ZHANG Hua,CHEN Ming,HUANG Qing,FU Wei-lin.DNA Methylation in Colorectal Carcinoma[J].Letters in Biotechnology,2009,20(1):118-122. | |
| Authors: | ZHANG Hua CHEN Ming HUANG Qing FU Wei-lin |
| Affiliation: | ZHANG Hua, CHEN Min, HUANG Qing, FU Wei-ling(1. Department of Clinical Laboratory, Guizhou Provincial People＇s Hospital, Guiyang 550002; 2. a. Department of Clinical Laboratory, Daping Hospital, Chongqing 400042; b. Department of Clinical Laboratory, South- west Hospital, Chongqing 400038; Third Military Medical University; China) |
| Abstract: | CpG islands of human genome, located mainly in the promoter as well as the first extron regions, are GC rich short stretches（100-1000 hp） and they link with 60% of human coding genes. Methylation of CpG sites in the promoter regions of genes can lead to decreased expression and silencing of the tumor suppressor genes and contribute to oneogenesis. Recently, DNA methylation has become one of epigenetics research hot spots. The research development of DNA methylation in colorectal carcinoma was reviewed in this article. |
| Keywords: | DNA methylation CpG islands colorectal carcinoma |
| 本文献已被 维普 万方数据 等数据库收录！ | |
