| 维生素C生物转化的代谢工程研究 |
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| 引用本文： | 袁红杰,张惟材.维生素C生物转化的代谢工程研究[J].生物技术通讯,2003,14(3):245-248. |
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| 作者姓名： | 袁红杰 张惟材 |
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| 作者单位： | 军事医学科学院,生物工程研究所,北京,100071 |
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| 摘 要： | 本从代谢工程角度出发，综述维生素C(Vc)生物转化代谢研究进展。分别论述了3条产生Vc重要前体2-酮基-L-古龙酸(2-KLG)反应路线的代谢机制、反应酶系及代谢工程菌构建等方面的问题；并对Vc生物转化应用前景作了展望。
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| 关 键 词： | 维生素C 生物转化 代谢工程 2－酮基－L－古龙酸 反应路线 代谢工程菌 |
| 文章编号： | 1009-0002(2003)03-0245-04 |
| 修稿时间： | 2003年3月24日 |
Research progress in the metabolic engineering for the conversion of vitamin C by bacteria |
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| YUAN Hong-jie,ZHANG Wei-cai.Research progress in the metabolic engineering for the conversion of vitamin C by bacteria[J].Letters in Biotechnology,2003,14(3):245-248. |
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| Authors: | YUAN Hong-jie ZHANG Wei-cai |
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| Abstract: | Base on the theory of metabolic engineering,the progress in the conversion of vitamin C by bacteria was reviewed.The metabolic mechanism,enzymes and the construction of the recombinant strains of producing2-keto-L-gluonic acid,an important precursor,in three metabolic pathway for the conversion of vitamin C were described.The future of this research area and possibility of application were discussed. |
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| Keywords: | metabolic engineering 2-keto-L-gluonic acid metabolic mechanism |
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