大分子的吸入治疗

随着重组DNA技术和分子生物学的发展，以蛋白质和多肽为主的大分子成为一类新型药物，并越来越受到重视，新兴的基因治疗技术使得核酸大分子也有可能成为药物。目前，绝大部分大分子药物都是通过注射途径给药，病人在医院注射费用昂贵且不方便，因而许多注射替代给药途径成为研究热门，通过肺部吸入给药就是一种很有吸引力的非侵入性给药途径。本介绍了肺吸收大分子的可能机制和大分吸入治疗的临床与基础研究以及面临的问题。

Inhalation therapy of macromolecules

Advances in molecular biology and recombinant DNA technology have led to the development of macromolecule as therapeutic agents for a variety of diseases including proteins, peptides and even nucleic acids. At present most of macromolecules are delivered by injection. Other routes of drug administration are being actively investigated. The inhalation therapy of macromolecule is an attractive noninvasive drug delivery method. In this review we describe the possible mechanisms of macromolecule absorption by the lung, then discuss the clinical and basic research of macromolecular inhalation therapy and analyze the problems of macromolecule inhalation delivery.