微生态调节剂在慢性重型肝炎患者的治疗作用

目的探讨微生态调节剂整肠生和乳果糖在慢性重型肝炎的治疗作用。方法 162例慢性重型肝炎患者被随机分为治疗组(84例)和对照组(78例)。对照组给予常规的综合治疗,治疗组在对照组的基础上给予整肠生胶囊4粒、乳果糖口服液10 ml每日3次口服,疗程为4周。比较2组病例治疗后主要症状和体征、肝功能、凝血功能、内毒素、血氨、并发症发生率及病死率。结果与对照组比较,治疗组更有效地改善患者临床症状、肝功能及凝血功能,降低血浆内毒素、血氨浓度,减少自发性腹膜炎(SBP)、肝性脑病(HE)和肝肾综合征(HRS)等并发症发生率和患者病死率。结论微生态制通过调整肠道失调菌群,能改善患者肝功能和凝血功能,降低血氨和内毒素血症,减少并发症和病死率,对慢性重型肝炎有明显治疗作用。

Microbial modulator in treatment of patients with severe chronic hepatitis

Objective To investigate the role of microbial modulator in the treatment of severe chronic hepatitis.Method 162 patients with severe chronic hepatitis were randomly divided into treatment group（84 cases） and control group（78 cases）.The control group received routine comprehensive treatment,while the treatment group was given 4 Zhengchangsheng capsules,with 10 ml of lactulose oral solution,3 times a day on the basis of routine treatment.The course of therapy was four weeks.After treatment,clinical data including main symptoms and signs,hepatic function,blood coagulable,endotoxin,ammonia,complications and fatality rates of the two groups were compared respectively.Result Compared with the control group,the clinical symptoms,hepatic function and blood coagulable,lowering plasma endotoxin and ammonia,reducing spontaneous bacterial peritonitis（SBP）,hepatic encephalopathy（HE）,hepatorenal syndrome（HRS） complications and fatality rate of the treatment group were improved more effectively.Conclusion Microbial modulator can improve patient′s liver function and blood coagulable,lower blood ammonia and endotoxin,reduce complications and fatality rate by adjusting the imbalance of intestinal flora.It has significant role in the treatment of severe chronic hepatitis.