| nm23-H1调控肿瘤侵袭转移分子机制研究进展 |
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| 引用本文： | 叶苏娟,朱文.nm23-H1调控肿瘤侵袭转移分子机制研究进展[J].生命科学,2009(1):107-111. |
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| 作者姓名： | 叶苏娟 朱文 |
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| 作者单位： | 四川大学华西医院生物治疗国家重点实验室,成都610041 |
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| 基金项目： | 国家自然科学基金项目（30571837）. |
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| 摘 要： | 侵袭转移是恶性肿瘤的重要生物学特征，也是导致肿瘤患者治疗失败和死亡的主要原因。研究表明，nm23基因家族与肿瘤的发生、发展及转移密切相关。其中，nm23-H1是被发现的第一个人类nm23基因，与肿瘤侵袭转移关系极为密切。现将nm23-H1基因调控肿瘤侵袭转移分子机制的研究进展作一综述。
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| 关 键 词： | nm23-H1基因 肿瘤 侵袭 转移 分子机制 肺肿瘤 乳腺肿瘤 |
Recent advances on the molecular mechanism of nm23-H1-regulated invasion and metastasis of tumors |
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| YE Su-juan,ZHU Wen.Recent advances on the molecular mechanism of nm23-H1-regulated invasion and metastasis of tumors[J].Chinese Bulletin of Life Sciences,2009(1):107-111. |
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| Authors: | YE Su-juan ZHU Wen |
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| Affiliation: | (State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China) |
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| Abstract: | Invasion and metastasis are not only the important traits of malignant tumors, but also the leading cause of failure to treatment for patients and their death. Many researches have shown that nm23 gene family has correlation to the genesis, development and metastasis of various tumors, nm23-H1 gene is the first gene of nm23 genes discovered in human. Furthermore, it has the closest relationship with the invasion and metastasis of tumors. In this review, we summarized the recent research advances on the molecular mechanism of nm23-H1- regulated invasion and metastasis of various tumors. |
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| Keywords: | nm23-H1 gene neoplasm invasion metastasis molecular mechanism lung carcinoma breast carcinoma |
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