The oxo/peroxo debate: a nonheme iron perspective |
| |
Authors: | Lawrence Que Jr |
| |
Affiliation: | (1) Department of Chemistry and Center for Metals in Biocatalysis, University of Minnesota, Minneapolis, MN 55455, USA |
| |
Abstract: | The oxygen activation mechanisms proposed for nonheme iron systems generally follow the heme paradigm in invoking the involvement of iron-peroxo and iron-oxo species in their catalytic cycles. However, the nonheme ligand environments allow for end-on and side-on dioxygen coordination and impart greater flexibility in the modes of dioxygen activation. The currently available evidence for nonheme iron-peroxo and iron-oxo intermediates is summarized and discussed in light of the ongoing discussion on the nature of the oxidant(s) in heme enzymes. |
| |
Keywords: | Iron(IV)-oxo Iron(III)-peroxo Model compounds Nonheme iron enzymes Oxygen activation |
本文献已被 SpringerLink 等数据库收录! |