血小板参数、hs—CRP与免疫球蛋白联合检测对肝炎患者的临床意义

目的：探讨和研究血小板参数、超敏C 反应蛋白（hs-CRP）与免疫球蛋白联合检测对肝炎患者的临床意义，为临床中肝炎患者的诊治提供参考。方法：收集各种病毒性肝炎患者共156 例（急性肝炎组48 例、慢性肝炎组56 例、重型肝炎组24 例和肝硬化组28 例），选择40 例健康体检者作为对照组，对5 组研究对象的血小板参数（（血小板计数（PLT）、平均血小板体积（MPC）、血小板压积（PCT）和血小板分布宽度（PDW））、血清超敏C 反应蛋白和免疫球蛋白（IgA、IgG 和IgM）水平进行检测和测定，并对这些指标的变化进行对比分析。结果：除重型肝炎组与肝硬化组的血小板计数（PLT），慢性肝炎组与重型肝炎组的PCT，急性肝炎组、肝硬化组与对照组3 组间的PDW 的差异无统计学意义外，任意两组之间的差异均有统计学意义（P＜0.05）；各组肝炎患者的hs-CRP 均比健康对照组显著升高（P〈0.01），且免疫球蛋白也较对照组差异有统计学意义。结论：肝炎患者的血小板参数、超敏C 反应蛋白（hs-CRP）与免疫球蛋白水平可以提示肝炎病情的变化，三者的联合检测为指导肝炎患者的判断、治疗方案的选择和疗效评定提供有一定的参考依据。

Clinical Significance of Platelet Parameters,hs CRP and Immunoglobulin Joint Detection in Patients with Hepatitis

Objective： To explore and research the clinical significance ofplatelet parameters, hypersensitive c-reactive protein （hs - CRP） and immune globulin combined detection in patients with hepatitis, and provide a reference for clinical diagnosis and treatment of patients with hepatitis. Methods： A total of 156 patients with various viral hepatitis （48 cases of acute hepatitis, 56 cases of chronic hep- atitis, 24 cases of fulminant hepatitis and 28 cases of hepatocirrhosis） were selected, 40 cases of healthy patients undergoing physical examination were chosen as control group. Platelet parameters, platelet count （PLT）, mean platelet volume （MPC）, platelet deposited （PCT） and platelet distribution width （PDW）, hypersensitive c-reactive protein and serum immunoglobulin （IgA, IgG, IgM） level of 5 groups were detected and measured, and the changes in these indicators were analyzed. Results： Except for that there were no significant difference in platelet count （PLT） between severe hepatitis group and liver cirrhosis group, in PCT between chronic of hepatitis group and severe hepatitis group, in PDW among 3 groups of acute hepatitis, liver cirrhosis group and the control group, the difference between any two groups were statistically significant （P〈0.05）; hs-CRP of groups of patients with hepatitis were significantly higher than the control group （P〈0.01）, and the difference in the immunoglobulin level were also statistically significant compared with control group. Conclusion： Platelet parameters, hypersensitive c-reactive protein （hs-CRP） and immunoglobulins levels of patients with hepatitis can indicate hepatitis condition changes, the joint detection of these tree indicators can provide a certain reference for the diagnosis of hepatitis, the choice of treatment and curative effect evaluation.