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慢性重度乙型肝炎患者肝组织中NF-κBp65和Caspase-3的表达及其意义
引用本文:郭晓东,张芋月,胡瑾华,熊璐,周光德,赵雨来.慢性重度乙型肝炎患者肝组织中NF-κBp65和Caspase-3的表达及其意义[J].生物磁学,2012(30):5838-5840,5901.
作者姓名:郭晓东  张芋月  胡瑾华  熊璐  周光德  赵雨来
作者单位:[1]解放军第302医院,北京100039 [2]总后丰台综合仓库(62370部队)药材供应站,北京100039
基金项目:国家”十二五”科技重大专项课题(2012ZX10002-003)
摘    要:目的:探讨慢性重度乙型肝炎患者肝组织中NF-κBp65和Caspase-3的表达及其意义。方法:选择慢性重度乙型肝炎肝组织标本68例(慢重肝组),正常肝组织标本20例(对照组)。采用免疫组化方法检测肝组织中NF-κBp65和Caspase-3的表达。结果:慢重肝组患者肝组织中NF-κBp65和Caspase.3阳性表达程度均明显强于对照组(P〈0.05);慢重肝患者死亡组肝组织中NF-κBp65和Caspase.3阳性表达程度均明显强于存活组(P〈O.05)。Spearman相关分析发现,慢重肝组患者肝组织中NF-κBp65和Caspase-3表达之间有明显的正相关性(r=0.449,P〈0.05)。结论:NF-κBp65和Caspase-3可能参与了慢性重度乙型肝炎的肝细胞凋亡过程,且具有一定相关性,并对判断患者预后有重要临床价值。

关 键 词:慢性重度乙型肝炎  NF-κBp65  Caspase-3  免疫组织化学

The Expression of NF-κBp65 and Caspase-3 in Liver Tissues of Chronic Severe Hepatitis B and the Significance
GUO Xiao-dong,ZHANG Ning-yue,HU Jin-hua,XIONG Lu,ZttOU Guang-de,ZHAO Yu-lai.The Expression of NF-κBp65 and Caspase-3 in Liver Tissues of Chronic Severe Hepatitis B and the Significance[J].Biomagnetism,2012(30):5838-5840,5901.
Authors:GUO Xiao-dong  ZHANG Ning-yue  HU Jin-hua  XIONG Lu  ZttOU Guang-de  ZHAO Yu-lai
Affiliation:1 302 Hospital of PLA Beijing, Beijing,100039, China; 2 Medical supply station of the General Logistics Department the Fengtai integrated warehouse (62370 troops),100039, China)
Abstract:Objective: To investigate the expression of NF-κBp65 and Caspase-3 in liver tissues of chronic severe hepatitis B and their significance. Methods: The specimens of the liver tissues in 68 cases with viral hepatitis gravis and 20 cases without liver diseases were detected for the expression of NF-K Bp65 and Caspase-3 by immtmohistochemical staining. Results: The expression of NF-κBp65 and Caspase-3 in viral hepatitis gravis group was significantly higher than those in control group (P〈0.05). The expression of NF-κBp65 and Caspase-3 in death group was significantly higher than those in living group (P〈0.05). There was a positive correlation between the expression of NF-K Bp65 and Caspase-3 (r=0.449, P〈0.05). Conclusion: NF-κBp65 and Caspase-3 with increased expression may participate in the hepatoeyteapoptosis of chronic severe hepatitis B. Therefore, they may be of great value for prognosis judging.
Keywords:Chronic severe hepatitis B  NF-κ Bp65  Caspase-3  Immunohistochemical staining
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