复治肺结核患者结核分枝杆菌L型培养结果分析

目的：了解复治肺结核患者的结核分枝杆菌L型培养情况，探讨结核分枝杆菌L型阳性与耐多药的关系。方法：选择180例肺结核患者的痰标本进行结核分枝杆菌培养和结核分枝杆菌L型培养，同时对110例复治组中培养阳性的标本行耐药监测。结果：复治组的L型阳性率为43．6％，初治组的L型阳性率为15．7％，复治组显著高于初治组（P〈0．01）；菌阳复治组的L型阳性率50％，菌阴复治组的L型阳性率39．4％，菌阳组明显高于菌阴组（P〈0．05）；L型菌阳性患者的耐药率显著高于L型菌阴性组（P〈0．05）。结论：结核分枝杆菌L型阳性是引起结核病复发、耐药的重要原因；MDR-TB与结核分枝杆菌L型感染有关。

Analysis of L-type Mycobacterium Tuberculosis Culture Results with Re-treated Pulmonary Tuberculosis Patients

Objective： To explore the culture results of L-type Mycobacterium tuberculosis with pulmonary tuberculosis patients. And to discuss the relationship between positive L-type Mycobacterium tuberculosis and the multi-drug resistance. Methods： Choose 180 pulmonary tuberculosis patients for sputum culture for Mycobacterium tuberculosis and L-type Mycobacterium tuberculosis. Meanwhile, for 110 re-treated patients group, conduct drug resistance monitoring with culture positive specimens. Results： The re-treated group, L-Type positive rate was 43.6%. For the initial treatment group, L-Type positive rate was 15.7%. Re-treated group was significantly higher than the initial treatment group （P 〈0.01）. re-treatment group with MTB positive had L-Type positive rate of 50%. While the re-treatment group with MTB negative had L-Type positive rate of 39.4%. For L-Type positive rate, the re-treatment group with MTB positive was significantly higher than that of MTB negative group （P 〈0.05）. L-type positive group had a significantly higher drug resistance rate than L-type negative group （P 〈0.05）. Conclusion： L-Type Mycobacterium tuberculosis positive is an important reason of pulmonary tuberculosis relapse and drug resistance, MDR-TB had a connection with L-type Mycobacterium tuberculosis infection.