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COX.2介导的TH2类细胞因子与重症肝炎的关系研究
引用本文:李斌,潘粉丽,常崇旺.COX.2介导的TH2类细胞因子与重症肝炎的关系研究[J].生物磁学,2009(2):268-270.
作者姓名:李斌  潘粉丽  常崇旺
作者单位:[1]第四军医大学唐都医院信息科,陕西西安710038 [2]第四军医大学唐都医院设备科,陕西西安710038 [3]第四军医大学唐都医院神经外科,陕西西安710038
基金项目:基金项目:国家自然科学基金资助项目(NO.30701005)
摘    要:目的:探讨重症肝炎与COX-2的关系,为临床防治重症肝炎提供新的治疗理论和方法。方法:用FH643A-γ测量仪检测50例肝病患者和25例正常对照血清中PGs代谢产物TXB2、6-keto-PGF1α的水平。结果:各组肝病患者血清中TXB2和6-keto-PGFlet的表达水平均明显高于正常人(P〈0.001),并且随着病情的好转,T/6-K比值明显下降,但肝病患者各组间细胞因子水平无显著性差异(p〉0.05)。结论:检测重症肝炎患者血清TXB2、6-keto—PGF1α的水平和T/6-K比值不仅对揭示肝病发生发展过程有一定的实用价值.而且对监测病情转归和预后有重要临床意义。

关 键 词:重症肝炎  COX-2  细胞因子

The TH2 Subgroup Cytokines Mediated Downstream Effector COX-2'S Function in the Progression of Serious Hepatitis
LI Bin,PAN Fen-Ii,CHANG Chong-wang.The TH2 Subgroup Cytokines Mediated Downstream Effector COX-2'S Function in the Progression of Serious Hepatitis[J].Biomagnetism,2009(2):268-270.
Authors:LI Bin  PAN Fen-Ii  CHANG Chong-wang
Affiliation:1 Department of information, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038, China ; 2 Department of equipment, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038, China; 3 Department ofneurosurgery,Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038, China )
Abstract:Objective: To study the TH2 subgroup cytokines mediated downstream effector COX-2's function in the progression of serious hepatitis; Methods: Samples from a total of 50 serious hepatitis patients with well-characterised clinical profiles and 25 healthy controls were assessed by ELISA. Results: Compared with the healthy control group, serum TXB2 and 6-keto-PGFlodevel were uniformly elevated in all serious hepatitis patients (P〈0.01). But there was no significant difference of these eytokines levels among the different types of serious hepatitis patients (p〉0.05). Conclusions: Product of COX-2 metabolism TXB2 and 6ketoPGF 16-keto-PGFlctwere associated with the clinical progression of serious hepatitis, especially T/6-K ratio was an effective biological marker for prognosis and diagnosis for serious hepatitis.
Keywords:Serious hepatitis  COX-2  Cytokines
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