| Leptin介导的JAK/STAT信号通路对脂类代谢调节的研究进展 |
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| 引用本文： | 王文正,赵素梅,高士争.Leptin介导的JAK/STAT信号通路对脂类代谢调节的研究进展[J].细胞生物学杂志,2011(5). |
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| 作者姓名： | 王文正 赵素梅 高士争 |
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| 作者单位： | 云南农业大学云南省动物营养与饲料重点实验室; |
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| 基金项目： | 国家转基因重大专项(No.2009ZX08009140B); 国家自然科学基金(No.30660132)资助项目~~ |
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| 摘 要： | Leptin介导的JAK/STAT信号通路主要参与脂类代谢的调节。JAK/STAT信号通路激活后,CPT-1的表达水平升高,通过促进脂肪酸分解而参与脂类代谢的调节。本文主要介绍了近年来关于leptin介导的JAK/STAT信号通路的组成、作用机制、活性调节和leptin与受体结合激活细胞内多个信号通路如JAK/STAT、PI3K/Akt、MAPK等,以及这些信号通路对脂类代谢调节的最新研究进展。
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| 关 键 词： | leptin JAK/STAT通路 SOCS3 CPT-1 |
Research Progress on Leptin-mediated JAK/STAT Signaling Pathway in Lipid Metabolism |
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| Wen-Zheng Wang,Su-Mei Zhao,Shi-Zheng Gao.Research Progress on Leptin-mediated JAK/STAT Signaling Pathway in Lipid Metabolism[J].Chinese Journal of Cell Biology,2011(5). |
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| Authors: | Wen-Zheng Wang Su-Mei Zhao Shi-Zheng Gao |
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| Affiliation: | Wen-Zheng Wang,Su-Mei Zhao,Shi-Zheng Gao~* (Yunnan Key Laboratory of Animal Nutrition and Feed Science,Yunnan Agricultural University,Kunming 650201,China) |
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| Abstract: | Leptin-mediated JAK/STAT signaling pathway mainly involves in the regulation of lipid metabolism. Activated JAK/STAT signaling pathway increases the CPT-1 expression levels,involves in the regulation of lipid metabolism by promoting the synthesis of fatty acids.This article mainly focused on the latest research progress on component,mechanism and regulation of the Leptin-mediated JAK/STAT signaling pathway,the activation of some signaling pathways,such as JAK/STAT,PI3K/Akt and MAPK,induced by the combinatio... |
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| Keywords: | Leptin JAK/STAT pathway suppressor of cytokine signaling-3 carnitine palmitoyl transferase 1 |
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