Definition of the Th/ To ribonucleoprotein by RNase P and RNase MRP |
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Authors: | W Rossmanith R Karwan |
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Affiliation: | (1) Abt. Genexpression, Institut für Tumorbiologie-Krebsforschung der Universität Wien, Borschkegasse 8a, A-1090 Wien, Austria |
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Abstract: | We show that the Th/ To ribonucleoprotein is defined by (i) the co-immunoprecipitation of two RNAs, (ii) the co-immunoprecipitation of four major polypeptides and (iii) the quantitative immune recognition of both RNase P and RNase MRP. No serum was found that recognizes either one of these two enzymes exelusively. The specific co-immunoprecipitation of RNase MRP and RNase P by all Th/ To ribonucleoprotein autoantibodies indicates that the anti-Th/ To autoimmune response is directed against both enzymes in a quantitatively indistinguishable manner. Thus the Th/ To ribonucleoprotein is defined by RNase P and RNase MRP. |
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Keywords: | autoantibody autoantigen RNase P Th To |
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