| 人类白细胞抗原-G分子结构与功能 |
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| 引用本文： | 孙丰浩,段永刚,蔡志明.人类白细胞抗原-G分子结构与功能[J].国外医学：分子生物学分册,2013(6):355-359. |
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| 作者姓名： | 孙丰浩 段永刚 蔡志明 |
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| 作者单位： | [1]北京大学深圳医院,广东省深圳市518036 [2]汕头大学医学院,广东省汕头市515041 [3]深圳市第二人民医院（深圳大学第一附属医院）,深圳大学泌尿生殖研究所,广东省深圳市518035 |
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| 基金项目： | 国家自然科学基金（No.81070529,31271244）,广东省医学科研基金（No.B2012319） |
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| 摘 要： | 人类白细胞抗原G（humanleukocyteantigen．G，HLA—G）属于非经典的HLAI类分子，是机体内一个重要的免疫耐受分子。HLA—G分子可通过与受体结合直接抑制多种免疫活性细胞的生物学功能，或通过诱导产生免疫调节细胞间接抑制机体的免疫应答。研究显示，HLA-G基因多态性及分子表达在母胎免疫、器官移植、肿瘤的发生发展、感染和自身免疫中均有重要意义。
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| 关 键 词： | 人类白细胞抗原 免疫耐受 |
Structure and Function of Human Leukocyte Antigen-G Molecule |
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| Authors: | SUN Fenghao DUAN Yonggang CAI Zhiming |
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| Affiliation: | ( I Peking University Shenzhen Hospital, Shenzhen, Guangdong, 518036, China 2Shenzhen Second People＇s Hospital, The First Affiliated Hospital of Sherazhen University, Institute of Urology and Reproduction of Shenzhen University, Shenzhen, Guangdong, 518035, China Shantou University Medical College, Shantou, Guangdong, 515041, China) |
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| Abstract: | Human leukocyte antigen-G （HLA-G）, a non-classical HLA class I molecule, is an important immunotolerant. HLA-G can directly inhibit biological functions of immune cells by binding to receptors, or indirectly inhibit the immune response by inducing regulatory cells. Previous studies have shown that both gene polymorphisms and the expression of HLA-G are associated with maternal-fetal immunity, organ transplantation, tumor development, infection and autoimmune dis- ease. Here, we discuss the current advances of the function of HLA-G. |
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| Keywords: | human leukocyte antigen-G immune tolerance |
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