Plasma membrane signaling in HIV-1 infection |
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Authors: | Wasim Abbas Georges Herbein |
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Affiliation: | Department of Virology, EA 4266 “Pathogens & Inflammation”, SFR FED4234, University of Franche-Comte, CHRU Besançon, F-25030 Besançon, France |
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Abstract: | Plasma membrane is a multifunctional structure that acts as the initial barrier against infection by intracellular pathogens. The productive HIV-1 infection depends upon the initial interaction of virus and host plasma membrane. Immune cells such as CD4 + T cells and macrophages contain essential cell surface receptors and molecules such as CD4, CXCR4, CCR5 and lipid raft components that facilitate HIV-1 entry. From plasma membrane HIV-1 activates signaling pathways that prepare the grounds for viral replication. Through viral proteins HIV-1 hijacks host plasma membrane receptors such as Fas, TNFRs and DR4/DR5, which results in immune evasion and apoptosis both in infected and uninfected bystander cells. These events are hallmark in HIV-1 pathogenesis that leads towards AIDS. The interplay between HIV-1 and plasma membrane signaling has much to offer in terms of viral fitness and pathogenicity, and a better understanding of this interplay may lead to development of new therapeutic approaches. This article is part of a Special Issue entitled: Viral Membrane Proteins — Channels for Cellular Networking. |
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Keywords: | HIV-1 Plasma membrane Apoptosis Lipid raft Chemokine CD4 receptor |
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