低分子肝素对早发型重度子痫前期治疗对母婴结局的影响分析

目的:探讨低分子肝素对早发型重度子痫前期治疗情况,并分析治疗对母婴结局的影响。方法:选择我院2012年1月~12月收治的早发型重度子痫前期患者120例,随机分为观察组和对照组,每组60例。对照组给予常规治疗,观察组在对照组治疗基础上加用低分子肝素。比较两组血压、24 h尿量、尿蛋白定量、尿酸、血常规、凝血功能及孕周延长时间、围产儿结局和产妇并发症。结果:两组患者临床指标无差异(P0.05),治疗后两组血压、24 h尿量、尿蛋白定量均显著改善,观察组红细胞压积、纤维蛋白原降低明显高于对照组,而观察组患者的产妇并发症和围产儿不良结局发生率均低于对照组,且产妇孕周延长时间明显多于对照组,差异有统计学意义(P0.05)。两组患者的血小板、凝血酶原时间等治疗前后均无明显变化(P0.05)。结论:低分子肝素对早发型重度子痫前期的治疗能有效抑制高凝状态,改善肾功能,延长孕周时间,可有效减少患者并发症的发生,改善母婴预后,值得临床推广应用。

Low Molecular Heparin for the Treatment of Early Hairstyle Severe Preeclampsia Impact Analysis of Maternal and Infant Outcomes

Objective： To discuss low molecular heparin for the treatment of early hairstyle severe preeclampsia, and analyze the treatment effects on maternal and infant outcomes. Methods： 120 patients with early hairstyle severe preeclampsia in our hospital from January 2012 to December were selected and randomly divided into observation group and control group, 60 cases in each group. Patients in control group were given conventional treatment, patients i in the control group were given low molecular heparin besides treatment in the observation group. 24 h blood pressure, urine output, quantitative, uric acid, blood routine, urine protein, blood coagulation function and gestational age to extend the time, maternal complications and perinatal outcome in two groups were compared. Results： Clinical indicators of patients were similar between the two groups （P〉0.05）, blood pressure after treatment, 24 h urinary volume, urinary protein in two groups were significantly improved, of red blood cells deposited, fibrinogen decrease in observation group were significantly higher than those in the control group, patients with obstetric complications and the incidence of poor perinatal outcomes in the observation groupwere lower than those in the control group, and maternal gestational week was longer obviously than that in the control group, the difference was statistically significant （P〈0.05）. Platelet, prothrombin time and others before and after treatment of patients in two groups had no significant change （P〉0.05）.Conclusion： Low molecular heparin treatment for early hairstyle severe preeclampsia can effectively restrain high coagulation state, improve renal function, prolong gestational age, and also can effectively reduce the complications of patients, improve maternal and infant prognosis, thus is worthy of clinical popularization and application.