不同严重程度缺氧缺血性脑病患儿血清MMP-9、MMP-2、UA水平的表达及临床意义

目的:研究不同严重程度缺氧缺血性脑病患儿血清基质金属蛋白酶-9(MMP-9)、基质金属蛋白酶-2(MMP-2)、尿酸(UA)水平的表达及临床意义。方法:选取2015年4月-2017年4月本院收治的缺氧缺血性脑病患儿50例记为研究组,另取同期本院健康新生儿50例记为对照组,分别比较两组新生儿血清MMP-9、MMP-2及UA水平,对比研究组不同时期不同严重程度患儿血清MMP-9、MMP-2及UA水平,采用Preason相关性分析缺氧缺血性脑病病情严重程度与血清MMP-9、MMP-2、UA水平的关系。结果:研究组患儿发病后1d、发病后3d、发病后7d血清MMP-9、MMP-2及UA水平均明显高于对照组,差异有统计学意义(P0.05),且MMP-9水平先升高后降低,MMP-2、UA水平呈逐渐升高的趋势(P0.05)。轻度组、中度组、重度组患儿发病后3d的MMP-9、MMP-2、UA水平高于发病后1d,且随着病情的加重,呈逐渐上升的趋势,差异有统计学意义(P0.05)。经Preason相关性分析可得:缺氧缺血性脑病病情严重程度与血清MMP-9、MMP-2、UA水平均呈正相关(P0.05)。结论:缺氧缺血性脑病患儿随着病情的逐渐加重,其血清MMP-9、MMP-2及UA水平不断升高,呈正相关关系。

Expression and Clinical Significance of Serum MMP-9, MMP-2 and UA in Neonates with Hypoxic Ischemic Encephalopathy with Different Severity

ABSTRACT Objective: To study the expression and clinical significance of serum matrix metalloproteinase-9 (MMP-9), matrix metalloproteinase-2 (MMP-2) and uric acid (UA) in neonates with hypoxic ischemic encephalopathy with different severity. Methods: 50 neonates with hypoxic ischemic encephalopathy who were treated in our hospital from April 2015 to April 2017 were selected as study group, at the same time, 50 healthy neonates in our hospital were selected and recorded as control group. The levels of serum MMP-9,MMP-2 and UA were compared between the two groups, the levels of serum MMP-9, MMP-2 and UA in neonates with different severity in study group at different stages were compared, and the relationship between the severity of hypoxic ischemic encephalopathy and the levels of serum MMP-9, MMP-2 and UA was analyzed by Preason correlation. Results: The levels of serum MMP-9, MMP-2 and UA of study group 1d after onset, 3d after onset, 7d after onset were significantly higher than the control group(P<0.05), and the level of MMP-9 was increased first and then decreased, and the levels of MMP-2 and UA were increased gradually(P<0.05). The levels of MMP-9, MMP-2 and UA in the mild, moderate and severe group 3d after onset were higher than that of 1d after onset, with the aggravation of the disease, the trend was gradually rising, and the difference was statistically significant(P<0.05). The Preason correlation analysis showed that the severity of hypoxic ischemic encephalopathy was positively correlated with the levels of serum MMP-9, MMP-2 and UA (P<0.05). Conclusion: The levels of serum MMP-9, MMP-2 and UA in neonates with hypoxic-ischemic encephalopathy are increased with the gradual increase of the condition, and there is a positive correlation.