分子影像技术在转化医学中的应用*

摘要：基础医学、药物研发和临床医学是三个不同的的领域，因此这些领域的很多生命科学研究成果经常无法及时应用于临床实 践。转化医学是以疾病为中心，加速将基础研究的成果用于临床诊断和治疗中，旨在有效的将三个领域有机结合在一起。分子影 像学(molecular imaging, MI) 可在活体上、在细胞和分子水平对生物学过程成像并进行定性和定量研究，为转化医学的实现提供 了保证。分子影像技术采用无创的医学影像技术使活体状态下组织细胞中的特殊分子生物学特性得以直观揭示，主要用于对疾 病早期诊断、疾病分期（分层）、疗效监测、指导疾病的个体化治疗以及新药的研发等领域。本文主要介绍分子影像的技术特点、其 在转化医学中发挥的作用以及其在个体化治疗中临床意义进行综述。

Applications of Molecular Imaging Technology in Translational Medicine *

ABSTRACT:Basic medicine, drug development and clinical medicine are three different fields, so researchments of life science areas often can not be applied into clinical practice. Translational medicine,regarding disease as the center, aim to combine the three different areas effectively, which can accelerate the basic research results applying to clinical diagnosis and treatment. Molecular Imaging (MI) is a discipline that can visualize the biological processes at the cellular and molecular level and execute qualitative and quantitative research in vivo. It enables the biological characteristics of special molecular in tissue cells visually reveal in vivo by non-invasive medical imaging technology. Molecular imaging technique is mainly used in diagnosing disease earlier, staging disease (stratification), monitoring efficacy of therapy, guiding and individuating the treatment of disease and developing new drugs and other fields. Translational medicine is disease-centered, and to expedite the results of basic research for clinical diagnosis and treatment. This paper reviewed the characteristics of molecular imaging techniques, the role in translational medicine and particularly the clinical significance in individuali-zed treatment.