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| 母源性抗-HBs对新生儿接种乙型肝炎疫苗的远期影响 | |
| 引用本文： | 骆超,武巧珍,何凤香,许碧云,周乙华,胡娅莉.母源性抗-HBs对新生儿接种乙型肝炎疫苗的远期影响[J].现代生物医学进展,2010,10(4). |
| 作者姓名： | 骆超 武巧珍 何凤香 许碧云 周乙华 胡娅莉 |
| 作者单位： | 1. 东南大学临床医学院,江苏,南京,210009;南京大学医学院附属鼓楼医院,江苏,南京,210008 2. 南京大学医学院附属鼓楼医院,江苏,南京,210008 3. 东南大学临床医学院,江苏,南京,210009 |
| 基金项目： | 江苏省卫生厅科教兴卫工程医学重点学科(XK200709); 江苏省医学重点人才项目(RC2007005)基金; 南京市医学科技发展项目(课题号ZKM06050)基金; 江苏省医学分子技术重点实验室(BM2007208) |
| 摘 要： | 目的:观察新生儿体内母源性乙型肝炎表面抗体(抗-HBs)对乙型肝炎疫苗接种后抗体应答的远期影响。方法:2006年10月-2007年1月在南京大学医学院附属鼓楼医院产前检查并住院分娩的单胎足月妊娠妇女中,选择抗-HBs阳性孕妇32例,抗-HBs阴性孕妇32例,其新生儿均按0、1、6方案接种重组(酵母)乙型肝炎疫苗,检测两组儿童乙型肝炎疫苗第3针接种后2年血清抗-HBs浓度。结果:新生儿接种乙型肝炎疫苗第3针后2年,母源性抗-HBs阴性组与阳性组儿童抗-HBs阳性率分别为90.6%与87.5%,其抗-HBs几何平均浓度分别为73.48mIU/ml与75.49mIU/ml,两组间抗-HBs阳性率与GMC的差异均无统计学意义(P=1.000,P=0.778);6例母源性抗-HBs>1000mIU/ml儿童中1例抗-HBs转阴(16.7%),而母源性抗-HBs<1000mIU/ml组和母源性抗-HBs组的儿童抗-HBs转阴率分别仅为7.69%和11.1%,但差异无统计学意(P=0.811)。结论:新生儿目前按照0,1,6方案接种乙型肝炎疫苗,能够有效保护其抵抗乙型肝炎病毒的感染;母源性抗-HBs对新生儿接种乙型肝炎疫苗... |
| 关 键 词： | 母源性抗体 抗-HBs 乙型肝炎疫苗 抗体应答抑制 |
Long-term Influence of Maternal Anti-HBs On the Antibody Response to Hepatitis B Vaccine in Infants |
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| LUO Chao,WU Qiao-zhen,HE Feng-xiang,XU Bi-yun,ZHOU Yi-Hua,HU Ya-li.Long-term Influence of Maternal Anti-HBs On the Antibody Response to Hepatitis B Vaccine in Infants[J].Progress in Modern Biomedicine,2010,10(4). | |
| Authors: | LUO Chao WU Qiao-zhen HE Feng-xiang XU Bi-yun ZHOU Yi-Hua HU Ya-li |
| Abstract: | Objective: To clarify whether maternal anti-HBs in infants may interfere with the long-term antibody response to hepatitis B vaccine. Methods: We selected 64 infants who were born in Nanjing Drum Tower Hospital between October 2006 and January 2007and divided them into two groups based on their mothers' status of anti-HBs (positive or negative). All the children had been given three doses of a recombinant hepatitis B vaccine at 0, 1, and 6 months of age, respectively; 2 years after the third injection, seru... |
| Keywords: | Maternal antibody Anti-HBs Hepatitis B vaccine Inhibition of antibody response |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |
