COX-2 与mPGES-1 在肾透明细胞癌中的表达及临床意义

目的:探讨环氧合酶-2(COX-2)和膜结合型前列腺素E2合成酶1(mPGES-1)在肾透明细胞癌组织中的表达及临床意义。方法:采用免疫组化SP法分别检测49例肾透明细胞癌组织标本和21例正常肾组织标本中COX-2和mPGES-1的表达。结果:COX-2在正常肾组织中的阳性表达率为4.8%,在肾透明细胞癌组织中的阳性表达率为53.1%(P<0.05);mPGES-1在正常肾组织中的阳性表达率为4.8%,在肾透明细胞癌组织中的阳性表达率为40.8%(P<0.05);COX-2和mPGES-1的高表达均与肾透明细胞癌的病理分级和临床分期无相关性(P>0.05);COX-2和mPGES-1在肾透明细胞癌中的表达呈正相关(P<0.05),r=0.5。结论:COX-2和mPGES-1在肾透明细胞癌发生及发展过程中共同发挥重要作用;COX-2和mPGES-1可能成为肾透明细胞癌新的治疗靶点。

Expression and Clinical Significance of Cyclooxygenase-2 and Microsomal Prostaglandin E2 Synthase-1 in Clear Cell Renal Cell Carcinoma

Objective: To explore the expression and clinical significance of cyclooxygenase-2(COX-2) and microsomal prostaglandin E2 synthase-1(mPGES-1) in clear cell renal cell carcinoma.Methods: 49 cases of clear cell renal cell carcinoma tissues specimens and 21 cases of normal renal tissues specimens were used to detect the expression and the clinicopathological features of COX-2 and mPGES-1 in clear cell renal cell carcinoma by means of immunohistochemistry SP method.Results: COX-2 positive expres-sion rate in normal renal tissue was 4.8%.On the contrary,COX-2 positive expression rate in clear cell renal cell carcinoma was 53.1%(P<0.05).mPGES-1 positive expression rate in normal renal tissue was 4.8%.On the contrary,mPGES-1 positive expression rate in clear cell renal cell carcinoma was 40.8%(P<0.05).The overexpression of mPGES-1 and COX-2 was not correlated with the pathologic grad-ing and clinical staging of clear cell renal cell carcinoma(P>0.05).The expression of COX-2 was positively correlated with mPGES-1(P<0.05),r=0.5.Conclusion: COX-2 and mPGES-1 might play crucial roles in the occurrence and development of clear cell renal cell carcinoma in common;COX-2 and mPGES-1 may be the novel therapeutic targets for treatment of clear cell renal cell carcinoma.