| 纳米级南瓜肌醇提取物的制备及其降血糖作用研究 |
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| 引用本文： | 陈丹青,刘华奇,李彦娜,赵萍,夏涛.纳米级南瓜肌醇提取物的制备及其降血糖作用研究[J].天然产物研究与开发,2011,23(1):43-48,53. |
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| 作者姓名： | 陈丹青 刘华奇 李彦娜 赵萍 夏涛 |
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| 作者单位： | 1. 上海诺金科生物科技有限公司研发中心,上海,201201
2. 华东师范大学生命科学院,上海,200062 |
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| 基金项目： | 上海市农业科技成果转化项目 |
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| 摘 要： | 本文通过制备纳米级南瓜肌醇提取物(Nanoscale pumpkin inositol extract,NPIE),观察其对链脲佐菌素诱导的糖尿病模型C57小鼠的血糖调节作用,并与普通南瓜肌醇提取物(Common pumpkin inositol extract,CPIE)的降血糖作用比较。高、低剂量CPIE组和NPIE组分别灌胃500 mg/kg、250 mg/kg的CPIE和NPIE水溶液,阳性药组灌服250 mg/kg的盐酸二甲双胍水溶液,模型对照组灌服等体积的双蒸水,实验周期均为30 d。结果显示所制备的南瓜肌醇提取物含肌醇3.12%,多糖53.21%,其中NPIE粒度平均小于500 nm;经动物实验,各给药组对正常小鼠无明显急性降糖作用,对糖尿病小鼠体重也无影响;但NPIE高剂量组对糖尿病小鼠的随机血糖和空腹血糖均具有明显降低效果,并对其糖耐量有一定改善作用,整体降糖效果较阳性药物组略弱,较CPIE强。
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| 关 键 词： | 纳米级 南瓜肌醇 提取物 多糖 降血糖 |
Preparation of Nanoscale Pumpkin Inositol Extract and Its Hypoglycemic Effect |
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| CHEN Dan-qing,LIU Hua-qi,LI Yan-na,ZHAO Ping,XIA Tao.Preparation of Nanoscale Pumpkin Inositol Extract and Its Hypoglycemic Effect[J].Natural Product Research and Development,2011,23(1):43-48,53. |
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| Authors: | CHEN Dan-qing LIU Hua-qi LI Yan-na ZHAO Ping XIA Tao |
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| Affiliation: | CHEN Dan-qing1,LIU Hua-qi1,LI Yan-na1,ZHAO Ping1,XIA Tao21Shanghai Newgenco Bioscience Co.,Ltd,Shanghai 201201,China,2School of Life Science,East China Normal University,Shanghai 200062 |
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| Abstract: | In this paper,nanoscale pumpkin inositol extract(NPIE) was prepared,then its hypoglycemic effect was evaluated in Streptozocin(STZ)-induced diabetic mice and the effect compared to common pumpkin inositol extract(CPIE).The experiment was comprised of diabetic mice treated with the low-and high-dose(250 mg/kg and 500 mg/kg) of NPIE and CPIE,respectively,positive controls with Metformin Hydrochloride(Met),and model group administrated with distilled water.The experiment term was 30 days.The results showed tha... |
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| Keywords: | Nanoscale Pumpkin Inositol Extract Polysaccharide Hpyerglycemic |
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