Multicomponent reaction of amine,carbon disulfide,and fluoronitrobenzene via nucleophilic attack on the fluorinated carbon for the synthesis of nitrophenyl methylcarbamodithioates |
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| Authors: | Saeed Bahadorikhalili Sayyad Mohammadi Mehdi Asadi Maliheh Barazandeh Mohammad Mahdavi |
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| Affiliation: | 1. Institute of Mechanics, Iranian Space Research Center, Shiraz, Iran;2. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran;3. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran |
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| Abstract: | In this paper, multicomponent reaction of amine, carbon disulfide and fluoronitrobenzene is reported for the synthesis of nitrophenyl methylcarbamodithioate derivatives. The method is based on the nucleophilic attack of the activated methylcarbamodithioate salt to fluoronitrobenzene. Several starting materials are tested and successfully produced the corresponding nitrophenyl methylcarbamodithioate. A possible mechanism for the reaction is suggested. |
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| Keywords: | amine-CS2 reaction aromatic nucleophilic substitution multicomponent reaction nitrophenyl methylcarbamodithioate |
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