Effective synthesis of bicyclodienes via palladium-catalyzed asymmetric allylic alkylation and ruthenium-catalyzed cycloisomerization |
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Authors: | Nizam HAVARE |
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Affiliation: | 1. Department of Chemistry, School of Humanities & Sciences, Stanford University, Stanford, California 94305-5580, United States |
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Abstract: | n.3.0]Bicycles (n = 3–6) can be synthesized using palladium-catalyzed asymmetric allylic alkylation followed by ruthenium-catalyzed cycloisomerization. New types of triarylphosphino-1,2-diaminooxazoline ligands show the same high levels of enantioselectivity observed with Trost ligand when employed in Pd-catalyzed allylic alkylation reactions. The enyne products of these allylic alkylation reactions were further elaborated using a Ru-catalyzed redox isomerization process, for which a mechanism is proposed. |
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Keywords: | Synthetic method development asymmetric catalysis Tsuji-Trost
-reaction palladium-catalyzed asymmetric allylic alkylation ruthenium-catalyzed cycloisomerization |
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