Terminal C(sp3) H alkylation of internal alkenes via Ni/H-catalyzed isomerization |
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| Authors: | Zhen-Yu Wang Jia-Hao Wan Gao-Yin Wang Rui Wang Ruo-Xing Jin Quan Lan Xi-Sheng Wang |
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| Affiliation: | Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui 230026, PR China |
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| Abstract: | An efficient nickel-catalyzed reductive relay cross-coupling of internal alkenes with alkyl (or aryl) halides has been developed. This method has demonstrated broad substrate scope, mild reaction conditions and excellent terminal-selectivity. Moreover, this efficient strategy could be applied to the terminal-selective alkylation of isomeric mixtures of internal alkenes. |
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| Keywords: | Nickel-catalyzed Isomerization Alkylation Terminal-selectivity Internal alkenes |
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