Screening of Synthetic Cathinones by Potentiometric Sensor Array and Chemometrics |
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Authors: | Tatiana V Shishkanova Eva Pospí?ilová Vadim Prokopec |
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Affiliation: | Department of Analytical Chemistry, University of Chemistry and Technology, Technická 5, 16628 Prague 6, Czech Republic |
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Abstract: | This work demonstrates the analytical applicability of single ion-selective membranes (ISMs) and potentiometric sensor array to distinguish and detect cathinone derivatives. Potentiometric data from ISMs based on cation exchanger and varying content of calix4]arene derivative were processed by principal component analysis (PCA). Such a combination of methods allowed discriminating various individual synthetic cathinones and their recognition from the mixture comprising primary amines (substituted amphetamines+aminoindane). Analytical parameters of ISM containing 1wt % of calix4]arene derivative were sufficient to detect 1.0×10?4 mol.l?1 1-(4-fluorophenyl)-2-(ethylamino)butan-1-one and 2-(methylamino)-1-phenylbutan-1-one (buphedrone) in both model and saliva samples. |
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Keywords: | Synthetic cathinones Potentiometry PCA Saliva |
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