Ionic liquid-functional MCM-41 as a high effective catalyst for the synthesis of isatylidene malononitrile via Knoevenagel condensation |
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Affiliation: | Laboratory of Marine Green Fine Chemicals, College of Chemistry and Chemical Engineering, Lingnan Normal University, Zhanjiang 524048, PR China |
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Abstract: | Ionic liquid functional MCM-41 was synthesized, characterized and used as heterogeneous catalyst for the Knoevenagel condensation of isatins with malononitrile. A series of corresponding isatylidene malononitrile were obtained in high isolated yield (96–99%) at room temperature in a short time. The heterogeneous catalyst can be easily recovered by centrifugation and showed almost no loss of activity over 10 recycle experiments. At the same time, the gram-scale experiments showed excellent yields and provided a highly effective method for scale up applications. |
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Keywords: | Knoevenagel condensation Isatin Isatylidene malononitrile MCM-41 Ionic liquid |
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