| pH敏感铱、钌和铂配合物在肿瘤靶向荧光成像和治疗中的应用 |
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| 引用本文： | 张思琪,高丽华,赵华,王克志.pH敏感铱、钌和铂配合物在肿瘤靶向荧光成像和治疗中的应用[J].无机化学学报,2019,35(11):1974-1986. |
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| 作者姓名： | 张思琪 高丽华 赵华 王克志 |
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| 作者单位： | 北京师范大学化学学院, 放射性药物教育部重点实验室, 北京 100875,北京工商大学理学院, 北京 100048,北京工商大学理学院, 北京 100048,北京师范大学化学学院, 放射性药物教育部重点实验室, 北京 100875 |
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| 基金项目： | 北京市自然科学基金（No.2182028），北京师范大学一年级博士生交叉学科研究基金（No.BNUXKJC1803），国家自然科学基金（No.21541010）和北京师范大学分析测试基金资助项目 |
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| 摘 要： | 肿瘤组织的微酸性环境为肿瘤准确诊断和有效治疗提供了新思路。pH敏感性金属配合物因具有较高的物理化学稳定性，突出的光谱特性和肿瘤靶向性等性质，引起高度关注。本文综述了这种肿瘤酸性微环境的产生机制以及近年来对这种酸性微环境敏感的铱、钌、铂配合物作为肿瘤成像和治疗试剂的研究进展。
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| 关 键 词： | 金属配合物 pH敏感性 肿瘤成像 肿瘤治疗 |
| 收稿时间： | 2019/9/3 0:00:00 |
| 修稿时间： | 2019/9/24 0:00:00 |
pH-Sensitive Iridium, Ruthenium and Platinum Complexes for Tumor-Specific Fluorescence Imaging and Cancer Therapy |
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| ZHANG Si-Qi,GAO Li-Hu,ZHAO Hua and WANG Ke-Zhi.pH-Sensitive Iridium, Ruthenium and Platinum Complexes for Tumor-Specific Fluorescence Imaging and Cancer Therapy[J].Chinese Journal of Inorganic Chemistry,2019,35(11):1974-1986. |
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| Authors: | ZHANG Si-Qi GAO Li-Hu ZHAO Hua and WANG Ke-Zhi |
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| Affiliation: | Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China,School of Science, Beijing Technology and Business University, Beijing 100048, China,School of Science, Beijing Technology and Business University, Beijing 100048, China and Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China |
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| Abstract: | Acidic pH in tumor tissues provides a powerful platform for accurate tumor diagnosis and efficient therapy. The pH-sensitive iridium, ruthenium and platinum metal complexes have attracted increasing attention due to their high physicochemical stability, favorable spectral properties and tumor targetability. In this review, we summarize formation mechanisms of the acidic tumor microenvironment and recent advances on the acidic microenvironment-sensitive metal complexes of iridium, ruthenium and platinum for tumor imaging chemotherapy agents. |
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| Keywords: | metal complex pH sensitive tumor imaging tumor therapy |
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