| A Concise and Convenient Synthesis of Stilbenes via Benzils and Arylmethyldiphenylphosphine Oxides |
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| 作者姓名： | 孙逊 朱俊 钟晨 泉铉治 张晨 |
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| 作者单位： | Department of Chemistry of Natural Products, School of Pharmacy, Fudan University, Shanghai 200032, China |
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| 基金项目： | Project supported by the Science and Technology Development Foundation, Shanghai Bureau of Health （No. 054086） and the Shanghai Municipal Committee of Science and Technology （Nos. 05JC 14057, 054319901）. |
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| 摘 要： | A new and convenient synthetic method has been developed for the construction of stilbenes bearing electron-withdrawing group（s） by using benzils and arylmethyldiphenylphosphine oxides via sequences involving Wittig-Horner reaction and a rearrangement in the presence of t-BuOK in toluene under mild conditions. This approach could be readily applied to a facile synthesis of biologically important natural products, resveratrol and its derivatives, such as trimethoxystilbenes 1 （Z） and 2 （E）.
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| 关 键 词： | 氧化物 1 2-二苯乙烯 苯偶酰 芳基 甲基 二甲苯 |
| 收稿时间： | 2007-05-08 |
| 修稿时间： | 2007-10-24 |
A Concise and Convenient Synthesis of Stilbenes via Benzils and Arylmethyldiphenylphosphine Oxides |
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| SUN, Xun ZHU, Jun ZHONG, Chen IZUMI, Ken-Ji ZHANG, Chen.A Concise and Convenient Synthesis of Stilbenes via Benzils and Arylmethyldiphenylphosphine Oxides[J].Chinese Journal of Chemistry,2007,25(12):1866-1870. |
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| Authors: | SUN Xun ZHU Jun ZHONG Chen IZUMI Ken-Ji ZHANG Chen |
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| Affiliation: | 1. Tel.: 0086‐021‐54237127;2. Fax: 0086‐021‐54237607;3. Department of Chemistry of Natural Products, School of Pharmacy, Fudan University, Shanghai 200032, China |
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| Abstract: | A new and convenient synthetic method has been developed for the construction of stilbenes bearing electron‐withdrawing group(s) by using benzils and arylmethyldiphenylphosphine oxides via sequences involving Wittig‐Horner reaction and a rearrangement in the presence of t‐BuOK in toluene under mild conditions. This approach could be readily applied to a facile synthesis of biologically important natural products, resveratrol and its derivatives, such as trimethoxystilbenes 1 (Z) and 2 (E). |
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| Keywords: | stilbene substituted benzil arylmethyldiphenylphosphine oxide resveratrol |
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