| 红外光谱法测定聚(乳酸-苯丙氨酸)共聚物的含量 |
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| 引用本文： | 刘迎,魏荣卿,刘晓宁,王明.红外光谱法测定聚(乳酸-苯丙氨酸)共聚物的含量[J].光谱学与光谱分析,2009,29(3). |
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| 作者姓名： | 刘迎 魏荣卿 刘晓宁 王明 |
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| 作者单位： | 南京工业大学制药与生命科学学院,江苏,南京,210009 |
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| 基金项目： | 科技部创新基金，国家科技支撑计划，国家高技术研究发展计划(863计划) |
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| 摘 要： | 分别以苯丙氨酸和乳酸为原料合成了3-苯甲基-2,5-吗啉二酮(PMD)与丙交酯(LA),以PMD和LA作为聚合单体经开环聚合分别得到PMD均聚物(PPMD)、丙交酯均聚物(PLA)及聚(乳酸-苯丙氨酸)共聚物.对合成的均聚物进行红外分析,确定1 671.53和870.82 cm-1处的吸收峰分别为PPMD和PLA的特征峰.根据以上两种特征吸收峰并以朗伯-比耳定律为理论依据,建立了利用红外光谱法测定聚(乳酸-苯丙氨酸)共聚物含量的方法.实验测定的标准工作曲线为y=0.055 67x+0.1091,r=0.999 3.利用该标准工作曲线定量测定了共聚物组分含量,其结果与1H NMR测定值一致,相对误差在2%以内,证明红外光谱法可方便、快捷地测定聚(乳酸-苯丙氨酸)共聚物组分含量,且适用于其他聚(乳酸-氨基酸)共聚物的含量测定,具有一定的实用性及推广性.
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| 关 键 词： | 红外光谱法 丙交酯 3-苯甲基-2 5-吗啉二酮 聚(乳酸-苯丙氨酸) 含量测定 |
Determination of the Content of Poly(Lactic Acid-co-Phenylalanine) by Infrared Spectroscopy |
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| LIU Ying,WEI Rong-qing,LIU Xiao-ning,WANG Ming.Determination of the Content of Poly(Lactic Acid-co-Phenylalanine) by Infrared Spectroscopy[J].Spectroscopy and Spectral Analysis,2009,29(3). |
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| Authors: | LIU Ying WEI Rong-qing LIU Xiao-ning WANG Ming |
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| Affiliation: | LIU Ying,WEI Rong-qing,LIU Xiao-ning,WANG Ming College of Life Science , Pharmaceutical Engineering,Nanjing University of Technology,Nanjing 210009,China |
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| Abstract: | To improve the thermal stability of poly(lactic acid),poly(lactic acid-co-phenylalanine) was prepared by introducing the phenyl of phenylalanine to the side chain.3-phenylmethyl-2,5-morpholinedione(PMD) and lactide(LA) were synthesized using phenylalanine and lactic acid as raw materials,respectively. Subsequently,poly(lactic acid-co-phenylalanine),homopolymer of PMD(PPMD) and homopolymer of LA(PLA) were obtained by ring-opening polymerization of PMD and LA as monomer.The amount of phenyl had an effect on t... |
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