四极杆线性离子阱系统和预存干涉波的傅里叶逆变换技术

本文在回顾四极杆线性离子阱结构和原理的基础上,阐释了线性离子阱的电子系统和串联质谱的核心技术原理,介绍了预存干涉波的傅里叶逆变换技术在四极杆线性离子阱中的应用,特别是用于选择母离子。四极杆线性离子阱的加工精度要求适中、成本低、电路设计和控制(包括射频和直流)相对容易,使其在研发方面具有较大优势。线性离子阱特有的MS^n、碰撞冷却、较高的灵敏度和分辨率,以及选择性的离子储存和激发能力都使其拥有广阔的应用前景。预存干涉波的傅里叶逆变换技术的应用使得母离子被特异性驻留,而非母离子通过共振被甩出,提高了线性离子阱的分析能力。

Quadrupole Linear Ion Trap System and Stored Waveform Inverse Fourier Transform Technique

Based on reviewing the structure and principle of the quadrupole linear ion trap, this review explains the core technical principles of the linear ion trap electronic system and cascade mass spectrometry, and introduces the stored waveform inverse Fourier transform technique in quadrupole linear ions. The application in the well, especially how to select the parent ion. The quadrupole linear ion trap is a magical analyzer that analyzes ions with a mass-to-charge ratio of thousands or more. In the full scan mode, the ion trap still has high sensitivity, and its sensitivity is often 10-1 000 times higher than that of the quadrupole. Compared to other types of analyzers, MSⁿ of multi-stage tandem mass spectrometry can be achieved with a single linear ion trap, which is very useful for structural identification of analytes. The resonance-assisted alternating voltage is used to excite the parent ion and the fragment ion, which is the key to achieving cascade mass spectrometry. In addition, the quadrupole linear ion trap is relatively easy to manufacture, requires low processing accuracy, and is cost effective. This review will introduce the mechanical structure of the quadrupole linear ion trap and the technical principles of circuit implementation; describe how to apply collision induced dissociation and assisted RF to achieve linear ion trap tandem mass spectrometry; explain how to pass RF voltage and DC voltage in a linear ion trap. The cooperation is to capture and excite ions; finally, the practical application of the stored waveform inverse Fourier transform technique in selecting parent ions and separating adjacent mass ions is also demonstrated.