| ??????????????????о???? |
| |
| 引用本文： | 王继峰,江静,彭博,钟儒刚,应万涛,钱小红.??????????????????о????[J].质谱学报,2014,35(2):108-117. |
| |
| 作者姓名： | 王继峰 江静 彭博 钟儒刚 应万涛 钱小红 |
| |
| 作者单位： | 1. ??????????????????????﹤??????????100022??2. ????????????????о??????????????????о????????????????????????????????102206 |
| |
| 基金项目： | 国家重点基础研究“973项目”(2011CB910603);国家高技术研究发展计划(2012AA020203);北京市科技新星计划(Z121107002512014)资助 |
| |
| 摘 要： | ???????????????????????????????????????????????Σ????????????????????????????е????????????????????????????????????????????У????????????????????????????λ?????????????з?????????????????????????????????????漰??????????????????????????????????????????????????о???????λ?????????????????????????????????????????????о??????????????????????????????????????????????????????????????????????????????????????????????????????
|
| 关 键 词： | ????????? ???? ???? ?????????? |
Advance in Mass Spectrometry-Based Analysis of Intact Glycopeptides |
| |
| WANG Ji-feng,JIANG Jing,PENG Bo,ZHONG Ru-gang,YING Wan-tao,QIAN Xiao-hong.Advance in Mass Spectrometry-Based Analysis of Intact Glycopeptides[J].Journal of Chinese Mass Spectrometry Society,2014,35(2):108-117. |
| |
| Authors: | WANG Ji-feng JIANG Jing PENG Bo ZHONG Ru-gang YING Wan-tao QIAN Xiao-hong |
| |
| Affiliation: | 1. The College of Life Science and Bio-engineering, Beijing University of Technology, Beijing 100022, China;2. State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102206, China |
| |
| Abstract: | Glycosylation is a common form of protein post-translational modification and plays key roles in biological processes, which is closely related to the occurrence, development, diagnosis and treatment of various diseases. Although the rapid development of biological mass spectrometry-based technology offers great conveniences to identification of glycosylation sites, peptides sequences and glycan structures of glycoproteins respectively, the illumination of the linkage between proteins and glycans and the analysis of the structure of intact glycopeptides still face a lot of difficulties and challenges. Based on literature researches, the major directions of the field were determined. This review will focus on MS analysis of the site-specific intact glycopeptides and describes the development and prospects of biological mass spectrometry-based technology for the analysis of intact glycopeptides on many aspects, from ion source and mass analyzers to dissociation modes and the analysis of mass spectrometric data. |
| |
| Keywords: | glycosylation glycopeptide mass spectrometry glycoproteomics |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《质谱学报》浏览原始摘要信息 |
|
点击此处可从《质谱学报》下载全文 |
|
