g University of

400016, China)NCX plays an important role in the regulation of intracellular Ca~ 2 concentration in myocytes.During the cardiac ischemia/reperfusion injury,NCX has long been thought to be the principal pathway of Ca~ 2 overload,leading to mechanical and electrical dysfunction of cardiomyocytes.NCX inhibitors,the benzyloxyphenyl derivatives( KB-R7943,SEA0400,and SN-6),can selectively and effectively inhi