水产品嘌呤与人类痛风的相关性评估

高尿酸血症与痛风都是体内尿酸生成过多或排泄过少引起的嘌呤代谢性障碍疾病, 嘌呤是核酸氧化分解的代谢产物, 尿酸是嘌呤代谢的最终产物。随着社会进步和经济发展, 加上不良的饮食结构和生活习惯, 痛风病明显上升, 并引发三高病、糖尿病、肾病等相关疾病。本文对人体尿酸的生成途径、各年龄层的尿酸水平以及产生原因进行了综述, 并分析了痛风种类、临床症状及其发病机制、发展史等, 同时对各种水产类嘌呤水平进行了分类, 提出了预防高尿酸血症和痛风的建议, 以期为痛风患者选择性的摄食营养水产品、进行健康饮食提供参考。

Assessment of the correlation between aquatic purine and human gout

Hyperuricemia and gout are disorders of purine metabolism caused by excessive production or excretion of uric acid in vivo, purine is the metabolic product of oxidative decomposition of nucleic acid and uric acid is the final product of purine metabolism. With social progress and economic development, together with poor dietary structure and living habits, gout has increased significantly and caused three high diseases, diabetes, nephropathy and other related diseases. This paper reviewed the pathway of human uric acid production, uric acid level of different age groups and its producing causes, and analyzed the types, clinical symptoms, pathogenesis and development history of gout, in the meanwhile, classified purine levels of seafood, and put forward suggestions for prevention of hyperuricemia and gout, in order to selectively feed nutritious seafood and healthy diet provide reference for gout patients.