| 叶酸与5-甲基四氢叶酸的生物学特征与应用 |
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| 引用本文： | 连增林,刘康,顾锦华,成永之.叶酸与5-甲基四氢叶酸的生物学特征与应用[J].中国食品添加剂,2022(2). |
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| 作者姓名： | 连增林 刘康 顾锦华 成永之 |
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| 作者单位： | 北京金康和信药业科技有限公司;连云港金康和信药业有限公司;南通大学附属妇幼保健院（南通市儿童医院） |
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| 摘 要： | 叶酸在胚胎期、出生后以及成人期都非常重要,叶酸缺乏会导致多种疾病的发生。近年来,随着国内外相关文献报道,叶酸代谢过程中的关键酶亚甲基四氢叶酸还原酶和甲硫氨酸合成酶还原酶的基因存在多态性,导致个体存在叶酸代谢障碍,由此,对于5-甲基四氢叶酸的开发研究成为关键。本文对叶酸及其代谢过程进行综述,并介绍了活性叶酸及天然化叶酸的研究进展。
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| 关 键 词： | 叶酸 5-甲基四氢叶酸 亚甲基四氢叶酸还原酶 基因多态性 天然化叶酸 |
Biological characteristics and application of folic acid and 5-methyltetrahydrofolate |
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| LIAN Zenglin,LIU Kang,GU Jinhua,CHENG Yongzhi.Biological characteristics and application of folic acid and 5-methyltetrahydrofolate[J].China Food Additives,2022(2). |
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| Authors: | LIAN Zenglin LIU Kang GU Jinhua CHENG Yongzhi |
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| Affiliation: | (Beijing Jinkang Hexin Pharmaceutical Technology Co.,Ltd.,Beijing 100176;Lianyungang Jinkang Hexin Pharmaceutical Co.,Ltd.,Lianyungang 222000;Maternal and Child Health Care Hospital Affiliated to Nantong University(Nantong Children’s Hospital),Nantong 226006) |
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| Abstract: | Folic acid is very important in embryo,postnatal and adult.Folic acid deficiency can lead to many diseases.In recent years,with the related literature reports at home and abroad,the key enzymes,methylenetetrahyd rofolatereductase and methionine synthetasereductase,in folate metabolism process has gene polymorphism,resulting in individual folate metabolism obstacles,therefore,the development and research of 5-methyltetrahydrofolate has become the key.In this paper,folate and its metabolism were reviewed,and the research progress of active folate and natural folate was introduced. |
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| Keywords: | folate 5-methyltetrahydrofolate methylenetetrahydrofolatereductase gene polymorphism naturalized folate |
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