Optimization of emulsions |
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| Authors: | ME CARLOTTI R CARPIGNANO MR GASCO M TROTTA |
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| Affiliation: | Dipartimento di Scienza e Tecnologia del Farmaco;Dipartimento di Chimica Generale e Organica Applicata, Universitàdi Torino, Italy |
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| Abstract: | The optimization of three emulsions with predetermined components was performed by the aid of experimental design. Three different surfactants were compared: the salts of hexadecylhydrogenphosphate with diethanolamine, lysine and arginine respectively. Optimized microemulsions showed quite high stabilities towards centrifugation (30–60 min at 7000 rpm). The results showed that the counter-ion can affect the composition and stability of an emulsion. |
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| Keywords: | predetermined formulations o/w emulsions optimization factorial design central composite design |
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