益生菌缓解帕金森病相关症状的作用及机制研究进展

帕金森病(Parkinson’s disease,PD)是一种常见的脑部神经病变。近年来,越来越多的证据表明肠道菌群失调与PD的发生发展密切相关。由此提示,从肠道微生物角度出发,可能是治疗PD的新策略。益生菌是一类能够定植于宿主肠道并对机体健康发挥有益作用的活性微生物,对维持肠道微生态平衡具有重要的意义。研究表明,益生菌可通过肠-脑轴有效预防和改善PD,潜在的作用机制包括调节肠道微生态,减轻炎症反应和氧化应激损伤,促进神经营养因子的表达等。本文综述了肠道菌群在PD中的变化,肠道菌群在PD发病中的机制,益生菌对PD相关症状的改善作用及机制等,以期为益生菌预防和缓解PD提供理论基础。

Research Progress on the Effect and Mechanism of Probiotics in Relieving Parkinson's Disease Related Symptoms

Parkinson's disease (PD) is a common neurological disorder of the brain. In recent years, there is increasing evidence that intestinal flora dysbiosis is closely related to the occurrence and development of PD. This suggests that intestinal microorganisms may be a new strategy for the treatment of PD. Probiotics are a group of active microorganisms that can colonize the host gut and play a beneficial role in the health of the body, and are of great significance to maintaining the intestinal microecological balance. Studies have shown that probiotics can effectively prevent and improve PD through the gut-brain axis, and the potential mechanisms of action include regulating intestinal microecology, alleviating inflammatory response and oxidative stress damage, and promoting the expression of neurotrophic factors. This article reviews the changes of intestinal flora in PD, the mechanisms of intestinal flora in the pathogenesis of PD, and the improvement effect and mechanisms of probiotics on PD-related symptoms, in order to provide a theoretical basis for probiotics to prevent and alleviate PD.