微生物发酵法生产L-异亮氨酸的研究进展

L-异亮氨酸作为三大支链氨基酸之一，在食品、牲畜饲料和医药等领域都有广泛应用。微生物发酵法是目前生产L-异亮氨酸最主要的方法，选育优良的生产菌种和优化发酵控制工艺有助于提高L-异亮氨酸的产量。该文对L-异亮氨酸的生物合成途径及代谢调控机制、L-异亮氨酸产生菌的选育现状以及发酵控制工艺进行了系统综述，为后续利用微生物发酵法生产L-异亮氨酸的生产研究提供了参考。

Research progress of L-isoleucine production by microbial fermentation

As one of the three branched chain amino acids, L-isoleucine is widely used in the fields of food, livestock feed and medicine. Microbial fermentation method was currently the most important method for L-isoleucine production, breeding excellent production strains and optimizing fermentation control technology can help increase the production of L-isoleucine. In this paper, the biosynthetic pathway and metabolic regulation mechanism of L-isoleucine, the breeding status of L-isoleucine-producing strain, and the fermentation control process were systematically reviewed, which provided a reference for the follow-up research on the production of L-isoleucine by microbial fermentation method.