| 荔枝多酚对营养性肥胖小鼠减肥和增强免疫力作用研究 |
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| 引用本文： | 涂杜,张军丽,彭新宇,袁明贵,高彪,向蓉,徐志宏.荔枝多酚对营养性肥胖小鼠减肥和增强免疫力作用研究[J].食品研究与开发,2019,40(15):14-18. |
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| 作者姓名： | 涂杜 张军丽 彭新宇 袁明贵 高彪 向蓉 徐志宏 |
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| 作者单位： | 广东省农业科学院动物卫生研究所广东省兽医公共卫生公共实验室广东省畜禽疫病防治研究重点实验室农业部兽用药物与诊断技术广东科学观测实验站广东省中兽药工程技术研究中心 |
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| 基金项目： | 广东省科技计划项目（2015A020209080）；广州市科技计划项目（201604020138） |
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| 摘 要： | 建立营养性肥胖小鼠模型,探讨荔枝多酚(litchi polyphenol,LP)减肥和增强免疫力作用。72只C57BL/6小鼠随机分为正常组12只,饲喂基础饲料,高脂组60只,饲喂高脂饲料,饲喂高脂饲料4周后,60只小鼠随机分为模型组、左旋肉碱组(500 mg/kg)、荔枝多酚低剂量组(300 mg/kg)、中剂量组(400 mg/kg)、高剂量组(500 mg/kg),每组12只,动物继续饲喂高脂饲料,同时各组小鼠灌胃上述药物2周。试验结束后比较各组小鼠体重、脂肪重量、Lee's指数、脾脏指数和胸腺指数及免疫球蛋白A(immunoglobulin A, IgA)、免疫球蛋白G(immunoglobulin G,IgG)、免疫球蛋白M (immunoglobulin M ,IgM)含量。荔枝多酚高剂量组体重、Lee's指数、肠系膜、双肾周、附睾的脂肪重量显著低于模型组(p<0.05),中剂量组、低剂量组的双肾周、附睾湿重低于模型组(p<0.05);荔枝多酚高剂量组小鼠血清中的IgA含量显著高于模型组(p<0.05),中剂量、低剂量组的IgG、IgM 显著高于模型组。LP 对高脂饲料诱导的肥胖大鼠具有抑制饮食量、降低体重,具有明显的减肥和提高免疫力作用。
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| 关 键 词： | 荔枝多酚 营养性肥胖 Lee's指数 减肥 免疫力 |
| 收稿时间： | 2018/10/11 0:00:00 |
Research on Weight Lossing and Immunity Enhancement of Litchi Polyphenol in Nutritionally Obese Mice |
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| TU Du,ZHANG Jun-li,PENG Xin-yu,YUAN Ming-gui,GAO Biao,XIANG Rong,XU Zhi-hong.Research on Weight Lossing and Immunity Enhancement of Litchi Polyphenol in Nutritionally Obese Mice[J].Food Research and Developent,2019,40(15):14-18. |
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| Authors: | TU Du ZHANG Jun-li PENG Xin-yu YUAN Ming-gui GAO Biao XIANG Rong XU Zhi-hong |
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| Affiliation: | (Guangdong Open Laboratory of Veterinary Public Health, Guangdong Provincial Key Laboratory of Animal Disease Prevention, Scientific Observing and Experimental Station of Veterinary Drugs and Diagnostic Techniques of Guangdong Province, Ministry of Agriculture, Chinese Traditional Medicine Engineering Technology Research Center of Guangdong Province, Institute of Animal Health,Guangdong Academy of Agricultural Sciences, Guangdong 510640, Guangzhou, China) |
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| Abstract: | TU Du;ZHANG Jun-li;PENG Xin-yu;YUAN Ming-gui;GAO Biao;XIANG Rong;XU Zhi-hong(Guangdong Open Laboratory of Veterinary Public Health, Guangdong Provincial Key Laboratory of Animal Disease Prevention, Scientific Observing and Experimental Station of Veterinary Drugs and Diagnostic Techniques of Guangdong Province, Ministry of Agriculture, Chinese Traditional Medicine Engineering Technology Research Center of Guangdong Province, Institute of Animal Health,Guangdong Academy of Agricultural Sciences, Guangdong 510640, Guangzhou, China) |
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| Keywords: | litchi polyphenol nutritional obesity Lee's index weight lossing immunity |
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