北枳棋的醒酒和保肝作用研究进展

北枳棋（Hovenia dulcis）是治疗酒精中毒和保肝护肝的经典中药之一。近年来的研究表明：北枳犋能够延长醉酒时间并缩短因醉酒而引发的睡眠时间，加速体内酒精代谢，抑制乙醇所致的肌肉松弛，激活酒精代谢过程中重要的酶类，如乙醇脱氢酶（ADH）、乙醛脱氢酶（ALDH）、谷胱甘肽过氧化氢酶（GSH-PX）等。以酒精、四氯化碳（CCl4）、左旋半乳糖胺（D-GaIN）和脂多糖（LPS）等引发的肝损伤模型实验证明，北枳楔具有保肝作用，在一定程度上使得肝功能维持在正常的水平。本文对近年来有关北枳棋解酒保肝作用的研究进展进行了综述。

Research Progress of Hovenia dulcis＇ Antialcoholism and Liver Protection Effect

Hovenia dulcis is one of the classical chinese herbs for antialcoholism and liver protection. Recent researches showed that Ho venia dulcis could prolong ebriety time, shorten sleep time induced by intoxication, accelerate alcohol metabolism, inhibit muscle relaxation caused by ethanol, and activate important enzymes during alcohol metabolism, such as ADH, ALDH, GSHPX. Experiments on models of liver injury caused by alcohol, CC14, D GAIN, LPS and so on showed Hovenia dulcis had the liver protection effect and could maintain the liver function on the normal level to some extent. This paper reviewed recent researches on antialcoholism and liver protection effect of Hove nia dulcis.