响应面试验优化紫胶树脂钠盐为壁材制备VE微胶囊工艺

为探索紫胶树脂钠盐在微胶囊壁材上的应用，将VE作为芯材，采用喷雾干燥法制备VE微胶囊。以包裹率为目标，通过单因素试验和响应面优化试验设计，对制备工艺进行了优化和分析，得到最佳工艺条件为：乳化剂亲水疏水平衡值11、乳化剂用量0.833 g、芯壁比1∶2.2。在此工艺条件下，制得的VE微胶囊为表面光滑的球型颗粒，其包裹率为78.06%，载药量为31.8%。结果表明，以紫胶树脂钠盐为壁材的VE微胶囊具有良好的热稳定性和复溶性，内容物可在中性pH值或肠内环境下释出，是一种较好的新型食品微胶囊壁材。

Response Surface Methodology for Optimization of Microencapsulation of Vitamin E with Sodium Shellac as Wall Material

Sodium shellac, a thermoplastic polymer, has high surfactant activity. In this study, we attempted to fabricate
vitamin E microcapsule with sodium shellac as the wall material by spray drying. The optimization of process parameters for
improved microencapsulation efficiency was done using one-factor-at-a-time method and response surface methodology. It
turned out that the optimal conditions for preparing vitamin E microcapsule were as follows: hydrophile-lipophile balance
(HLB) of emulsifier, 11; emulsifier dosage, 0.833 g; and ratio of core to wall materials, 1:2.2. Under these conditions,
the microcapsules with microencapsulation efficiency of 78.06% and drug-loading efficiency of 31.8% were obtained as
spherical particles with a smooth surface. The vitamin E microcapsule had high thermal stability and good solubility, and it
exhibited good release performance at neutral pH or in the intestinal environment. Thus, sodium shellac potentially could be
used in the food industry as a good novel microcapsule wall material.