| DGA树脂辅助的循环淋洗技术制备无载体镥［177Lu］ |
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| 引用本文： | 卓连刚,杨宇川,岳海东,熊晓玲,王关全,王海麟,杨林,林青川,陈琪萍,涂俊,魏洪源.DGA树脂辅助的循环淋洗技术制备无载体镥［177Lu］[J].同位素,2022,35(3):217. |
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| 作者姓名： | 卓连刚 杨宇川 岳海东 熊晓玲 王关全 王海麟 杨林 林青川 陈琪萍 涂俊 魏洪源 |
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| 作者单位： | 中国工程物理研究院 核物理与化学研究所，四川 绵阳621999；国家卫生健康委员会核技术医学转化重点实验室（绵阳市中心医院），四川 绵阳621099；医学与分子影像四川省重点实验室，四川 绵阳621999 |
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| 摘 要： | 为实现核医学广泛关注的新型医用放射性同位素177Lu的国产规模化，利用中国绵阳反应堆（CMRR）进行无载体（n.c.a.）177Lu的制备工艺研究。在常规的镧系树脂分离纯化177Lu的流程中加入可以吸附洗脱液中金属离子的DGA树脂柱，并通过特殊的流路连接方式，实现淋洗镧系树脂柱洗脱液的“在线”循环。示踪实验和三次生产流程验证表明，第一级分离的废液量降低>86%。质检分析表明，循环淋洗技术制备的无载体177Lu产品符合质量要求。研究表明，该技术显著降低了镧系树脂分离无载体177Lu中的放射性酸废液总量，可用于规模化生产工艺。
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| 关 键 词： | 无载体177Lu 医用同位素 177Lu分离 DGA树脂 |
Preparation of No-Carrier-Added 177Lu by DGA Resin Assisted Cyclic Elution |
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| ZHUO Liangang,YANG Yuchuan,YUE Haidong,XIONG Xiaoling,WANG Guanquan,WANG Hailin,YANG Lin,LIN Qingchuan,CHEN Qiping,TU Jun,WEI Hongyuan.Preparation of No-Carrier-Added 177Lu by DGA Resin Assisted Cyclic Elution[J].Isotopes,2022,35(3):217. |
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| Authors: | ZHUO Liangang YANG Yuchuan YUE Haidong XIONG Xiaoling WANG Guanquan WANG Hailin YANG Lin LIN Qingchuan CHEN Qiping TU Jun WEI Hongyuan |
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| Affiliation: | China Academy of Engineering Physics Institute of Nuclear Physics and Chemistry, Mianyang 621999, China;NHC Key Laboratory of Nuclear Technology Medical Transformatio, Mianyang 621099, China;Key Laboratory of Nuclear Medicine and Molecular Imaging of Sichuan Province, Mianyang 621999, China |
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| Abstract: | A preparation process of No-Carrier-Added (NCA) 177Lu in China Mianyang Research Reactor (CMRR）was investigated. In this work, the key component of the process is DGA resin column which can adsorb Yb(Ⅲ) and Lu(Ⅲ) metal ions in the eluent was added to the purification process of 177Lu. The eluent “on-line” cyclic elution of lanthanide resin column was realized through special flow path connection. The tracer test showed that this technology can effectively reduce the volume of radioactive acid waste liquid generated from purification process of 177Lu. The technology was verified in three batches production, and the primary separation stage reduced the volume of waste liquid above 86%. The NCA 177Lu product prepared by cyclic elution process meets the quality requirements. |
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| Keywords: | no-carrier-added 177Lu DGA resin medical isotopes 177Lu separations |
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